CAJ | 학술논문

采用饱和溶液法制备奥硝唑与β-环糊精的包合物，采用显微镜法、红外光谱法对包合物进行了鉴定，并评价包合物溶解性与稳定性．通过L9（34）正交试验设计考察包合物的制备工艺．试验结果表明：奥硝唑与β-环糊精可形成可溶性包合物，可提高奥硝唑的溶解性和稳定性．包合物的最佳制备条件为奥硝唑∶β-环糊精＝1∶1，包合时间为3 h ，包合温度为60℃．包合物收率为73．10％，包合率为24．53％．
채용포화용액법제비오초서여β-배호정적포합물，채용현미경법、홍외광보법대포합물진행료감정，병평개포합물용해성여은정성．통과L9（34）정교시험설계고찰포합물적제비공예．시험결과표명：오초서여β-배호정가형성가용성포합물，가제고오초서적용해성화은정성．포합물적최가제비조건위오초서∶β-배호정＝1∶1，포합시간위3 h ，포합온도위60℃．포합물수솔위73．10％，포합솔위24．53％．
Ornidazole β-cyclodextrin inclusion complexes were prepared by saturated water so-lution ,and their structures were characterized by microscope and IR .The solubility and sta-bility of ornidazole β-cyclodextrin inclusion complexes were evaluated .The preparation condi-tion were selected by L9 (34 ) orthogonal experimental design .Results have shown that ornidazole and β-cyclodextrin can form inclusion complex ,and the aqueous solubility and sta-bility were increased when ornidazole was included by β-cyclodextrin .The optimum prepara-tion conditions of ornidazole β-cyclodextrin inclusion complexes were established as follows :the quality ratio of ornidazole and β-cyclodextrin was 1∶1 ,reaction time for was 3 h ,inclu-sion temperature was 60 ℃ ,and yield was 73 .10% ,the inclusion rate of the complex was 24 .53% .