CAJ | 학술논문

目的：探讨1～6月龄正常婴儿听性脑干反应（ABR）的变化规律，建立小婴儿ABR波I、III、V潜伏期及波间期正常参考值。方法对166例（269耳）1月龄、141例（226耳）2月龄、111例（177耳）3月龄、58例（96耳）4月龄、78例（121耳）5月龄和45例（76耳）6月龄正常婴儿进行短声（click）ABR测试，分析反应阈及各波潜伏期、波间期。结果1～6月龄正常婴儿ABR反应阈均值为16．18±5．35dBnHL，波V潜伏期均值9．03±0．49ms，各月龄组反应阈差异无统计学意义（P＞0．05）。在80dBnHL刺激声强度时，波I、III、V引出率均为100％，随着刺激声强的降低，以波V的稳定性最好，波I消失最快，各波潜伏期均延长，标准差增大，各波间期缩短。在同一刺激声强下，随着月龄的增长，波I潜伏期无明显变化，波III、V潜伏期和I-III、III-V、I-V波间期均有明显缩短。在4月龄前波III、V潜伏期和I-III、III-V、I-V波间期各月龄组间差异均有统计学意义（P＜0．05），4月龄后各月龄组间的差异无统计学意义（P＞0．05）。结论本组1～6月龄正常婴儿短声诱发听性脑干反应反应阈的正常值为16．18±5．35dBnHL；下丘以下听觉神经传导径路在出生后1～4月有较快的发育过程。
목적：탐토1～6월령정상영인은성뇌간반응（ABR）적변화규률，건립소영인ABR파I、III、V잠복기급파간기정상삼고치。방법대166례（269이）1월령、141례（226이）2월령、111례（177이）3월령、58례（96이）4월령、78례（121이）5월령화45례（76이）6월령정상영인진행단성（click）ABR측시，분석반응역급각파잠복기、파간기。결과1～6월령정상영인ABR반응역균치위16．18±5．35dBnHL，파V잠복기균치9．03±0．49ms，각월령조반응역차이무통계학의의（P＞0．05）。재80dBnHL자격성강도시，파I、III、V인출솔균위100％，수착자격성강적강저，이파V적은정성최호，파I소실최쾌，각파잠복기균연장，표준차증대，각파간기축단。재동일자격성강하，수착월령적증장，파I잠복기무명현변화，파III、V잠복기화I-III、III-V、I-V파간기균유명현축단。재4월령전파III、V잠복기화I-III、III-V、I-V파간기각월령조간차이균유통계학의의（P＜0．05），4월령후각월령조간적차이무통계학의의（P＞0．05）。결론본조1～6월령정상영인단성유발은성뇌간반응반응역적정상치위16．18±5．35dBnHL；하구이하은각신경전도경로재출생후1～4월유교쾌적발육과정。
Objective To investigate the characteristics of click -auditory brainstem response (ABR) in nor-mal infants of 1 to 6 months old ,and to establish the normative values for latencies of Wave I ,III ,V and interpeak latencies of I- Ⅲ ,III-V and I-V for younger infants .Methods Click auditory brainstem responses were recorded from infants within 6 months :166 infants of 1 -months old(269 ears) ,141 2 -month old (226 ears) ,111 3 -months old(177 ears) ,58 4-months old(96 ears) ,78 5-months old(121 ears) and 45 6-months old(76 ears) .We compared the latencies of wave I ,III ,V and interpeak latencies of I - Ⅲ ,III-V ,I-V obtained from infants of differ-ent ages at different stimulus intensities .Results The average threshold of 1 to 6 months infants was 16 .18 ± 5 .35 dB nHL ,the average latency of Wave V was 9 .03 ± 0 .49 ms .The differences among the thresholds were statistical-ly insignificant(P>0 .05) .Wave I ,III and V were noticeable in all ears tested at 80 dB nHL .Wave I disappeared first as the stimulus intensity decreased ,and the latencies of Wave I ,III and V prolonged;on the contrary ,interpeak latencies of I -III ,III-V ,I-V shortened significantly .At the same stimulus intensity ,the latencies of Wave III , V and the interpeak latencies of I - Ⅲ ,III-V ,I-V shortened significantly except for Wave I .When comparing the differences among the testing parameters as a function of each month ,we found that there were statistically signifi-cant differences for the latencies of wave III ,V and the interpeak latencies of I -III ,III-V ,I-V before the 4 months old(P<0 .05) ,and there were no significant differences after 4 months old(P>0 .05) .Conclusion It is recommen-ded that 16 .18 ± 5 .35 dB nHL be used as the normative references for the evoked threshold of click auditory brain-stem responses for 1~6 month old infants .The development of central nervous system below the inferior calicles is fast before the 4 months old .