CAJ | 학술논문

目的：探讨男性睾酮（T）及雄激素结合蛋白（ABP）与饮水氟暴露的关系。方法：应用现况调查研究，在河南省某县随机选择7个村庄作为调查点，分别为高氟村2个、改水村2个和对照村3个；采集各调查点生活饮用水。整群抽取所选调查点本地出生的18～50岁男性作为调查对象，分别采集晨尿和空腹静脉血。应用氟离子选择电极法测定饮用水和尿中氟含量，采用ELISA法测定血清 ABP水平，采用化学发光免疫分析法测定血清T。结果：高氟组饮水氟浓度为（2．44±1．88） mg/L，高于对照组的（0．37±0．15） mg/L和改水组的（0．36±0．30） mg/L （F＝12．289，P＜0．001）。高氟组尿氟浓度为（2．49±1．40） mg/L，高于对照组的（1．04±0．49） mg/L 及改水组的（1．38±0．67） mg/L（F＝71．563， P＜0．001），改水组亦高于对照组（P＜0．05）。高氟组血清ABP含量为（16．01±10．83） nmol/L，低于对照组的（27．94±31．90） nmol/L 及改水组的（22．42±28．12） nmol/L（F＝28．807， P＜0．001）。对照组、改水组、高氟组血清T含量为（4．31±1．30）、（4．42±1．37）和（4．74±2．17） nmol/L，差异无统计学意义（F＝0．268， P＝0．765）。在对照组和改水组中，血清T含量与年龄呈负相关（β＝-0．238、-0．262，P均＜0．05）。结论：环境氟暴露可影响男性血清ABP水平。
목적：탐토남성고동（T）급웅격소결합단백（ABP）여음수불폭로적관계。방법：응용현황조사연구，재하남성모현수궤선택7개촌장작위조사점，분별위고불촌2개、개수촌2개화대조촌3개；채집각조사점생활음용수。정군추취소선조사점본지출생적18～50세남성작위조사대상，분별채집신뇨화공복정맥혈。응용불리자선택전겁법측정음용수화뇨중불함량，채용ELISA법측정혈청 ABP수평，채용화학발광면역분석법측정혈청T。결과：고불조음수불농도위（2．44±1．88） mg/L，고우대조조적（0．37±0．15） mg/L화개수조적（0．36±0．30） mg/L （F＝12．289，P＜0．001）。고불조뇨불농도위（2．49±1．40） mg/L，고우대조조적（1．04±0．49） mg/L 급개수조적（1．38±0．67） mg/L（F＝71．563， P＜0．001），개수조역고우대조조（P＜0．05）。고불조혈청ABP함량위（16．01±10．83） nmol/L，저우대조조적（27．94±31．90） nmol/L 급개수조적（22．42±28．12） nmol/L（F＝28．807， P＜0．001）。대조조、개수조、고불조혈청T함량위（4．31±1．30）、（4．42±1．37）화（4．74±2．17） nmol/L，차이무통계학의의（F＝0．268， P＝0．765）。재대조조화개수조중，혈청T함량여년령정부상관（β＝-0．238、-0．262，P균＜0．05）。결론：배경불폭로가영향남성혈청ABP수평。
Aim:To explore the relationship between environmental fluoride exposure and the concentration of serum androgen binding protein (ABP) as well as testosterone (T) of male adults.Methods:A cross-sectional study was conduc-ted in 7 villages of Tongxu county including 2 endemic fluorosis villages ( EFV ) ,2 EFV implemented with defluoridation project villages(DFPV) and 3 control villages (CV).Males who aged 18 to 50 years born in the villages were recruited u-sing cluster sampling .Drinking water , urine and blood samples were collected .The fluoride levels of drinking water and u-rine samples were detected by fluoride-ion selective electrode method .ABP was determined using ELISA method and T was determined using chemiluminescence method .Results: The fluoride concentrations in drinking water were ( 2.44 ± 1.88), (0.36 ±0.30) and (0 3.7 ±0 .15) mg/L in EFV, DFPV and CV, respectively (F=12.289,P<0.001).It was significantly higher in EFV than those in DFPV and CV (P<0.05).Compared with DFPV[(1.38 ±0.67) mg/L]and CV [(1.04 ±0.49) mg/L], the urinary fluoride concentration of EFV[(2.49 ±1.40) mg/L]was higher(F=71.563, P<0.001),and there was a significant difference between DFPV and CV (P<0.05).Serum ABP level of adults from EFV [(16.01 ±10.83) nmol/L] was significantly lower than that from DFPV [(22.42 ±28.12) nmol/L] and CV[(27.94 ± 31.90) nmol/L] (F=28.807, P<0.001).No significant differences were observed in serum T concentration among three groups (F=0.268, P=0.765).There was a negative relationship between T and age of men who were investigated in CV and DFPV(β=-0.238,-0.262,P<0.05).Conclusion:Environmental fluoride exposure may affect serum ABP level in male .