CAJ | 학술논문

目的：探讨高血压对学习记忆能力的影响。方法：取自发性高血压（ SH ）大鼠和对照Wistar-Kyoto大鼠各7只，采用标准Ⅱ导联记录心电图，尾套法测定鼠尾动脉压，采用Y型迷宫和跳台实验测试大鼠的学习记忆能力，采用Western blot法检测脑组织小电导钙激活钾通道蛋白2（ SK2）的表达。结果：与对照比较， SH大鼠鼠尾动脉压增高（t＝12．060，P＜0．001），QRS时长和R-R间期延长（t＝3．147，3．917，P＜0．05），Y型迷宫实验学习次数减少（t＝3．279，P＝0．007），跳台实验上台次数和上台受电击总时间增加（t＝4．626，2．516，P＜0．05）；脑组织SK2蛋白表达也较对照组增加。结论：SK通道可能参与了高血压大鼠认知损害的过程。
목적：탐토고혈압대학습기억능력적영향。방법：취자발성고혈압（ SH ）대서화대조Wistar-Kyoto대서각7지，채용표준Ⅱ도련기록심전도，미투법측정서미동맥압，채용Y형미궁화도태실험측시대서적학습기억능력，채용Western blot법검측뇌조직소전도개격활갑통도단백2（ SK2）적표체。결과：여대조비교， SH대서서미동맥압증고（t＝12．060，P＜0．001），QRS시장화R-R간기연장（t＝3．147，3．917，P＜0．05），Y형미궁실험학습차수감소（t＝3．279，P＝0．007），도태실험상태차수화상태수전격총시간증가（t＝4．626，2．516，P＜0．05）；뇌조직SK2단백표체야교대조조증가。결론：SK통도가능삼여료고혈압대서인지손해적과정。
Aim:To explore the influence of hypertension on learning and memory capacity .Methods:A total of 7 spontaneously hypertensive rats were used to detect arterial pressure with tail-trussed method , ECG was recorded using standard lead Ⅱ,and the learning and memory capacity was measured using Y-type electric maze and the jumping stand measurements , and Western blot was used to determine the expression of SK 2 protein in brain tissue .Wistar-Kyoto rats were the control .Results: Compared with those of the control , arterial pressure of spontaneously hypertensive rats was higher(t=12.060,P<0.001), QRS duration and R-R interval prolonged(t=3.147,3.917,P<0.05),the learning times during Y-type electric maze measurements was less (t=3.279,P=0.007), the times of jumping onto the platform and the total time of shock increased(t=4.626,2.516,P<0.05), and the expression of SK2 protein in brain tissue was higher. Conclusion:SK channel may be associated with learning and memory damages of spontaneously hypertensive rats .