CAJ | 학술논문

目的：评价Artemin蛋白在胃癌组织中的表达情况及其与胃癌临床病理特征的关系。方法：应用免疫组化的方法检测122例胃癌组织和98例癌旁正常胃组织中Artemin蛋白的表达情况，分析其与胃癌临床病理特征之间的关系。结果：胃癌组织中Artemin蛋白阳性表达率（77．1％，94/122）高于癌旁正常胃组织（16．3％，16/98；χ2＝80．154，P＜0．001）。 Artemin蛋白阳性表达率随着胃癌浸润程度的加深和TNM分期的增加而逐渐升高（ P均＜0．05）；Artemin蛋白的表达与淋巴结转移有关（χ2＝17．835，P＜0．001），与胃癌的分化程度、患者的性别、年龄无关（P均＞0．05）。结论：Artemin可能参与了胃癌的发生发展，且与侵袭转移密切相关。
목적：평개Artemin단백재위암조직중적표체정황급기여위암림상병리특정적관계。방법：응용면역조화적방법검측122례위암조직화98례암방정상위조직중Artemin단백적표체정황，분석기여위암림상병리특정지간적관계。결과：위암조직중Artemin단백양성표체솔（77．1％，94/122）고우암방정상위조직（16．3％，16/98；χ2＝80．154，P＜0．001）。 Artemin단백양성표체솔수착위암침윤정도적가심화TNM분기적증가이축점승고（ P균＜0．05）；Artemin단백적표체여림파결전이유관（χ2＝17．835，P＜0．001），여위암적분화정도、환자적성별、년령무관（P균＞0．05）。결론：Artemin가능삼여료위암적발생발전，차여침습전이밀절상관。
Aim:To investigate the expression of Artemin protein in gastric carcinoma tissue and its relationship with clinicopathologic features of gastric carcinoma .Methods:Immunohistochemistry was used to detect the expression of Arte -min protein in 122 cases of gastric cancer tissue and 98 cases of normal gastric mucosa.The relationship between the expressionof Artemin protein and clinicopathologic features of gastric cancer was analyzed .Results: The positive rate of Arteminprotein expression in gastric cancer tissue (77.1%, 94/122) was higher than that in normal gastric mucosa(16.3%,16/98; χ2 =80.154, P <0.001).The positive rate of Artemin protein expression gradually increased with thedeepened tumor invasion degree and increased TNM staging (P <0.05); the expression of Artemin protein was relevantwith lymph node metastasis (χ2 =17.835,P <0.05) but not relevant with the degree of gastric cancer differentiation , genderor age of the patients (P >0.05).Conclusion: Artemin may be involved in the occurrence and development of gastriccancer and is closely related with invasion and metastasis .