CAJ | 학술논문

研究了南非紫菜(Porphyra capensis)多糖(PCP)对自然衰老小鼠抗氧化活性及免疫器官的影响。将PCP以三个剂量(50、100、200(mg/(kg)?d）)腹腔注射给药,连续给药20 d,可以显著提高衰老小鼠的脾脏和胸腺指数,提高衰老小鼠SOD和GSH-Px的活力及总抗氧化能力,在高剂量时降低衰老动物的 MDA 的含量。PCP 能够提高衰老小鼠的免疫机能和机体的抗氧化能力,是一种比较理想的抗衰老保健产品。
연구료남비자채(Porphyra capensis)다당(PCP)대자연쇠로소서항양화활성급면역기관적영향。장PCP이삼개제량(50、100、200(mg/(kg)?d）)복강주사급약,련속급약20 d,가이현저제고쇠로소서적비장화흉선지수,제고쇠로소서SOD화GSH-Px적활력급총항양화능력,재고제량시강저쇠로동물적 MDA 적함량。PCP 능구제고쇠로소서적면역궤능화궤체적항양화능력,시일충비교이상적항쇠로보건산품。
The effects of polysaccharide from Porphyra capensis (PCP) on the immune system and the antioxidative capacity in ageing mice were investigated in this study. PCP with different dose (50, 100 and 200 mg/kg respec-tively) was intraperitoneally injected to ageing Kunming mice daily for 20 days, and its effects on the thymus and spleen indices, serum MDA level, SOD, GSH-Px activities and the total antioxidative capacity in spleen and lung of the animals were measured. The results showed that thymus and spleen indices of ageing mice were significantly increased by PCP. PCP enhanced the SOD and GSH-Px activities and the total antioxidative capacity in ageing mice. PCP at high dose decreased the MDA level in ageing mice. The enhancing effect of PCP on the immune function and the antioxidative capacity of ageing mice indicated that PCP might be a potential anti-ageing drug candidate.