中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2013年
9期
59-61
,共3页
肝炎%乙型%慢性%肝组织%病理学
肝炎%乙型%慢性%肝組織%病理學
간염%을형%만성%간조직%병이학
Hepatitis B%Chronic%Hepatic tissue%Pathology
目的：探讨ALT＜2倍正常上限慢性乙型肝炎病毒感染者肝组织病理学变化情况及其与肝脏生化、纤维化指标的关系。方法：对102例ALT＜2倍正常上限慢性乙型肝炎病毒感染者，行经皮肝穿刺活体组织检查，判断其肝组织炎症坏死分级和纤维化程度分期，并根据病理分级、分期分别分为G0～1、G2、G3～4组和S0～1、S2、S3～4组，比较各组之间肝脏生化及纤维化指标水平的差异。结果：102例炎症坏死分级≥G2者60例（58．82％），纤维化程度分期≥S2者55例（53．92％）。按照不同炎症坏死分级及纤维化分期，各组肝脏生化指标水平比较，差异无统计学意义（P＞0．05）；纤维化指标Ⅲ型前胶原、透明质酸水平，G0～1和G2组均低于G3～4组，S0～1和S2组均低于S3～4组，差异均有统计学意义（P＜0．05）。结论：肝脏生化指标不能很好反映ALT＜2倍正常上限慢性乙型肝炎病毒感染者肝脏病变严重程度，肝纤维化指标Ⅲ型前胶原、透明质酸有重要参考价值，肝穿刺活检仍是判定肝脏炎症和纤维化程度的金标准。
目的：探討ALT＜2倍正常上限慢性乙型肝炎病毒感染者肝組織病理學變化情況及其與肝髒生化、纖維化指標的關繫。方法：對102例ALT＜2倍正常上限慢性乙型肝炎病毒感染者，行經皮肝穿刺活體組織檢查，判斷其肝組織炎癥壞死分級和纖維化程度分期，併根據病理分級、分期分彆分為G0～1、G2、G3～4組和S0～1、S2、S3～4組，比較各組之間肝髒生化及纖維化指標水平的差異。結果：102例炎癥壞死分級≥G2者60例（58．82％），纖維化程度分期≥S2者55例（53．92％）。按照不同炎癥壞死分級及纖維化分期，各組肝髒生化指標水平比較，差異無統計學意義（P＞0．05）；纖維化指標Ⅲ型前膠原、透明質痠水平，G0～1和G2組均低于G3～4組，S0～1和S2組均低于S3～4組，差異均有統計學意義（P＜0．05）。結論：肝髒生化指標不能很好反映ALT＜2倍正常上限慢性乙型肝炎病毒感染者肝髒病變嚴重程度，肝纖維化指標Ⅲ型前膠原、透明質痠有重要參攷價值，肝穿刺活檢仍是判定肝髒炎癥和纖維化程度的金標準。
목적：탐토ALT＜2배정상상한만성을형간염병독감염자간조직병이학변화정황급기여간장생화、섬유화지표적관계。방법：대102례ALT＜2배정상상한만성을형간염병독감염자，행경피간천자활체조직검사，판단기간조직염증배사분급화섬유화정도분기，병근거병리분급、분기분별분위G0～1、G2、G3～4조화S0～1、S2、S3～4조，비교각조지간간장생화급섬유화지표수평적차이。결과：102례염증배사분급≥G2자60례（58．82％），섬유화정도분기≥S2자55례（53．92％）。안조불동염증배사분급급섬유화분기，각조간장생화지표수평비교，차이무통계학의의（P＞0．05）；섬유화지표Ⅲ형전효원、투명질산수평，G0～1화G2조균저우G3～4조，S0～1화S2조균저우S3～4조，차이균유통계학의의（P＜0．05）。결론：간장생화지표불능흔호반영ALT＜2배정상상한만성을형간염병독감염자간장병변엄중정도，간섬유화지표Ⅲ형전효원、투명질산유중요삼고개치，간천자활검잉시판정간장염증화섬유화정도적금표준。
Objective:To explore the changes of liver tissue pathology of ALT <2 ULN Chronic HBV inflected persons and the relation of the changes , liver biochemistry and fibrosis index .Methods:102 cases between the two groups of ALT <2 ULN chronic HBV inflected patients were examined of their percutaneous transhepatic puncture biopsy , judge their liver tissue inflammation and necrosis grade and the degree of fibrosis staging .According to pathological grading and staging , the patients were divided into G 0~1、G2、G3~4 group and S0~1、S2、S3~4 group, and compare the difference of liver biochemistry and fibrosis indexes .Results:Among 102 patients, 60 patients'inflammation and necrosis grading≥G2 (58.82%),55 patients'degree of fibrosis staging≥S2 (53.92%).According to the different in-flammation and necrosis grading and degree of fibrosis staging , each group's liver biochemical indexes level was compared , there were no significant differences (P>0.05);PCⅢand HA of G 0~1 group and G2 group were lower than G3~4 group, PCⅢand HA of S0~1 group and S2 group were lower than S3~4 group, there were significant differences (P<0.05).Conclusion:Liver biochemical indexes cannot reflect the severity of liver disease of ALT <2 ULN Chronic HBV inflected persons , PCⅢand HA had important reference value , needle biopsy of liver is still the best standard to judge inflammation of the liver and the degree of fibrosis .
