CAJ | 학술논문

以手性磷酸作为催化剂，研究了3-亚甲基异吲哚-1-酮与吲哚的不对称傅克烷基化反应。通过对催化剂、溶剂及反应温度等条件的优化，发现在室温条件下，以(S)-1-萘基取代的手性磷酸CPA-5为催化剂，在二氯甲烷溶剂中，反应可以获得51%的对映选择性。在此条件下，考察了吲哚的取代基效应，获得优秀的反应收率和39%~64%的ee值。
이수성린산작위최화제，연구료3-아갑기이신타-1-동여신타적불대칭부극완기화반응。통과대최화제、용제급반응온도등조건적우화，발현재실온조건하，이(S)-1-내기취대적수성린산CPA-5위최화제，재이록갑완용제중，반응가이획득51%적대영선택성。재차조건하，고찰료신타적취대기효응，획득우수적반응수솔화39%~64%적ee치。
Friedel-Crafts alkylation reaction of 3-methylene-isoindol-1-one and indoles catalyzed by chiral phosphoric acid was studied. With the optimization of catalyst, solvent and reaction temperature, the optimum catalyst was (S)-1-naphthyl replaced CPA-5 chiral phosphoric acid, optimum solvent was dichloromethane. The reaction could obtain 51% stereoselectivity under the room temperature. Under these conditions, the substituent effect of indole was investigated, good reaction yield and 39%~64%ee were obtained.