中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2013年
10期
37-40
,共4页
焦虑和抑郁评分%血糖%血脂%血浆纤维蛋白原
焦慮和抑鬱評分%血糖%血脂%血漿纖維蛋白原
초필화억욱평분%혈당%혈지%혈장섬유단백원
Anxiety and depression disorders scores%Fasting plasma glucose%Blood lipids%Plasma ifbrinogen
目的：探讨慢性焦虑、抑郁障碍与血糖、血脂及血浆纤维蛋白原（Fg）水平的相互关系，进而为了解精神因素与躯体疾病之间的精神生物学机制提供线索。方法按照DMS-Ⅳ标准，对本院神经科于2012年12月至2013年4月间新入院的患者，由同一位有经验的精神科临床医师对他们进行入院前20～30年或更长时期以来的精神状态包括焦虑和抑郁两个方面进行严重程度评分，同时采集患者入院当日或次日血样，化验检测其空腹血糖、血脂及血浆Fg水平，然后进行统计分析，了解患者慢性焦虑、抑郁评分与其当前血糖、血脂及血浆Fg水平之间的关系。结果统计分析显示，焦虑障碍评分与血糖、血脂各指标之间无显著相关性（P＞0.05），与血浆Fg水平之间呈显著负相关（P＜0.01）；抑郁障碍评分与血糖、血脂各指标及血浆Fg水平之间均未显示有显著相关性（P＞0.05）。有焦虑组与无焦虑组做比较，有焦虑组血浆Fg水平明显低于无焦虑组（P＜0.01）。有焦虑组血糖水平低于无焦虑组，但无显著差异（P＝0.094）。结论慢性焦虑有降低血浆Fg水平的作用，从而对血栓形成性疾病如脑梗死、冠心病等可能有保护作用。
目的：探討慢性焦慮、抑鬱障礙與血糖、血脂及血漿纖維蛋白原（Fg）水平的相互關繫，進而為瞭解精神因素與軀體疾病之間的精神生物學機製提供線索。方法按照DMS-Ⅳ標準，對本院神經科于2012年12月至2013年4月間新入院的患者，由同一位有經驗的精神科臨床醫師對他們進行入院前20～30年或更長時期以來的精神狀態包括焦慮和抑鬱兩箇方麵進行嚴重程度評分，同時採集患者入院噹日或次日血樣，化驗檢測其空腹血糖、血脂及血漿Fg水平，然後進行統計分析，瞭解患者慢性焦慮、抑鬱評分與其噹前血糖、血脂及血漿Fg水平之間的關繫。結果統計分析顯示，焦慮障礙評分與血糖、血脂各指標之間無顯著相關性（P＞0.05），與血漿Fg水平之間呈顯著負相關（P＜0.01）；抑鬱障礙評分與血糖、血脂各指標及血漿Fg水平之間均未顯示有顯著相關性（P＞0.05）。有焦慮組與無焦慮組做比較，有焦慮組血漿Fg水平明顯低于無焦慮組（P＜0.01）。有焦慮組血糖水平低于無焦慮組，但無顯著差異（P＝0.094）。結論慢性焦慮有降低血漿Fg水平的作用，從而對血栓形成性疾病如腦梗死、冠心病等可能有保護作用。
목적：탐토만성초필、억욱장애여혈당、혈지급혈장섬유단백원（Fg）수평적상호관계，진이위료해정신인소여구체질병지간적정신생물학궤제제공선색。방법안조DMS-Ⅳ표준，대본원신경과우2012년12월지2013년4월간신입원적환자，유동일위유경험적정신과림상의사대타문진행입원전20～30년혹경장시기이래적정신상태포괄초필화억욱량개방면진행엄중정도평분，동시채집환자입원당일혹차일혈양，화험검측기공복혈당、혈지급혈장Fg수평，연후진행통계분석，료해환자만성초필、억욱평분여기당전혈당、혈지급혈장Fg수평지간적관계。결과통계분석현시，초필장애평분여혈당、혈지각지표지간무현저상관성（P＞0.05），여혈장Fg수평지간정현저부상관（P＜0.01）；억욱장애평분여혈당、혈지각지표급혈장Fg수평지간균미현시유현저상관성（P＞0.05）。유초필조여무초필조주비교，유초필조혈장Fg수평명현저우무초필조（P＜0.01）。유초필조혈당수평저우무초필조，단무현저차이（P＝0.094）。결론만성초필유강저혈장Fg수평적작용，종이대혈전형성성질병여뇌경사、관심병등가능유보호작용。
Objective For the purpose to Understand the mechanisms of the interaction between the spirit and the body, in this article, we tried to explore the correlation between the scores of chronic anxiety and depression disorders of the patients and the concentrations of the fasting plasma glucose, blood lipids and plasma ifbrinogen of the same patients. Methods According to the diagnostic criteria of anxiety, depression in DMS-Ⅳ, all the patients who were admitted in our hospital neurological department from December 2012 to April 2013 were scored in severity about chronic anxiety and depression disorders for the past 20 ~ 30 years or more by a same experienced psychiatric clinician. At the same time, all the patients’ fasting plasma glucose, blood lipids and plasma ifbrinogen concentrations were checked. Then, the relationship between the scores of chronic anxiety and depression disorders and the concentrations of the fasting plasma glucose, blood lipids and plasma ifbrinogen were analyzed. Results Anxiety disorders scores have on signiifcant correlation with the concentrations of fasting plasma glucose and blood lipids (P>0.05), but it has a signiifcant Reversed correlation with plasma ifbrinogen concentrations (P<0.01);Depression disorders scores have on correlation with fasting plasma glucose, blood lipids and plasma ifbrinogen concentrations(P > 0.05);Compared with the group without anxiety disorders, the group with anxiety disorders has lower fasting plasma glucose concentration, but the Statistical significance is not obvious (P = 0.094). Conclusion Chronic anxiety disorders maybe play a role of decreasing the plasma ifbrinogen concentration of the Patients, therefore it may be a protective factor for the thrombotic diseases such as cerebral infarction, coronary heart disease et al.
