CAJ | 학술논문

目的：探讨食管癌合并脉管瘤栓患者的临床病理特点、与P53、Ki67、表达和5年生存率的关系。方法：回顾性分析84例食管癌合并脉管瘤栓患者的临床病理资料、P53、Ki67表达和5年生存率。结果：食管癌合并脉管瘤栓患者的淋巴结转移数目越多脉管瘤栓发生率越高（P＜0．01）；瘤细胞分化程度低/未分化癌较高/中分化的脉管瘤栓有显著意义（P＜0．01）；食管癌合并脉管瘤栓与免疫组化P53、Ki67阳性与阴性比较有差异（P＜0．05）。食管癌患者5年生存率在脉管瘤栓阳性与阴性表达患者之间比较有显著差异（P＜0．05）。结论：食管癌合并脉管瘤栓的发生与食管癌患者的年龄、性别无关；与临床病理的淋巴结转移数目及P53、Ki67的阳性表达呈正相关关系，与细胞分化程度表达呈负相关关系，合并脉管瘤栓患者预后差。把脉管瘤栓加入现行的TNM分期中结合P53、Ki67联合检测可能更具有临床指导意义。
목적：탐토식관암합병맥관류전환자적림상병리특점、여P53、Ki67、표체화5년생존솔적관계。방법：회고성분석84례식관암합병맥관류전환자적림상병리자료、P53、Ki67표체화5년생존솔。결과：식관암합병맥관류전환자적림파결전이수목월다맥관류전발생솔월고（P＜0．01）；류세포분화정도저/미분화암교고/중분화적맥관류전유현저의의（P＜0．01）；식관암합병맥관류전여면역조화P53、Ki67양성여음성비교유차이（P＜0．05）。식관암환자5년생존솔재맥관류전양성여음성표체환자지간비교유현저차이（P＜0．05）。결론：식관암합병맥관류전적발생여식관암환자적년령、성별무관；여림상병리적림파결전이수목급P53、Ki67적양성표체정정상관관계，여세포분화정도표체정부상관관계，합병맥관류전환자예후차。파맥관류전가입현행적TNM분기중결합P53、Ki67연합검측가능경구유림상지도의의。
Objective:To investigate the merger of esophageal cancer in patients with vascular invasion clinical and pathological fea -tures,and P53, Ki67, expression and 5 year survival .Methods:A retrospective analysis of 84 cases of esophageal cancer in patients with vascular invasion combined clinical and pathological data , P53, Ki67 expression and 5-year survival rate.Results:Esophageal cancer combined vascular invasion of lymph node metastasis in patients with the more higher the incidence of vascular invasion ( P <0.01 );poorly differentiated tumor cells /undifferentiated carcinoma , high /medium differentiation of vascular invasion was significant ( P <0. 01);esophageal combined vascular invasion and immunohistochemical P 53, Ki67-positive compared with negative differences (P <0. 05) .5-year survival rate of patients with esophageal cancer tumor thrombus in the vascular expression of positive and negative patients there was a significant difference between ( P <0.05 ) .CONCLUSION:Esophageal cancer incidence of vascular invasion combined with esophageal cancer patient's age, sex;lymph node metastasis and clinical pathology number and P 53, K6i7 positive expression was posi-tively correlated with the degree of cell differentiation expression was negatively correlated , the combined vascular tumor thrombus in pa-tients with poor prognosis .Pulse tube tumor thrombus into the existing TNM staging combined P 53, Ki67 combined detection may be more clinical significance .