CAJ | 학술논문

建立高效液相色谱仪测定盐酸雷尼替丁制剂含量的检测方法。采用磷酸盐缓冲液与乙腈等比混合的流动相等度洗脱，于314 nm检测，外标法定量。盐酸雷尼替丁质量浓度在5～500μg/mL范围内与色谱峰面积线性相关，相关系数大于0.9999。6次测定结果的相对标准偏差为0.85%，加标回收率为(100±2)%。该法操作简便、清洁高效、准确可靠，可用于盐酸雷尼替丁片和胶囊含量的测定。
건립고효액상색보의측정염산뢰니체정제제함량적검측방법。채용린산염완충액여을정등비혼합적류동상등도세탈，우314 nm검측，외표법정량。염산뢰니체정질량농도재5～500μg/mL범위내여색보봉면적선성상관，상관계수대우0.9999。6차측정결과적상대표준편차위0.85%，가표회수솔위(100±2)%。해법조작간편、청길고효、준학가고，가용우염산뢰니체정편화효낭함량적측정。
A monitoring method with HPLC detection of ranitidine amount in medicine was set up. The result was gained by detecting the ranitidine chromatographic peak of the sample with HPLC in KH2PO4 solution-acetonitrile by isocratic elution and quantited by the standard curve. The concentration of ranitidine was linear with chromatographic peak area in the range of 5-500μg/mL with the correlation coefficent more than 0.999 9. RSD was 0.85%(n=6)and the recovery rate was (100±2)%. The method was handy operation, lower consumption and dependable, which can be used to detect the content of tablet and capsule of ranitidine.