CAJ | 학술논문

目的：研究肌电生物反馈联合早期康复对急性脑梗死患者临床疗效和血清基质金属蛋白酶-9(MMP-9)水平的影响。方法90例急性脑梗死偏瘫患者，采用随机数字表法分为对照组(n=30)、康复组(n=30)和综合组(n=30)。所有患者均接受常规药物治疗，康复组采用早期康复，综合组采用肌电生物反馈联合早期康复，治疗2周。于治疗前后采用临床神经功能缺损评分(CNFDS)及改良Barthel指数(MBI)进行评定，检测血清MMP-9水平。结果治疗后，各组CNFDS评分显著下降， MBI评分显著升高(P<0.001)，综合组明显优于康复组、对照组(P<0.01)。各组血清MMP-9水平下降，综合组下降更明显(P<0.001)。结论肌电生物反馈联合早期康复可促进神经功能的恢复，机制可能与降低血清MMP-9水平有关。
목적：연구기전생물반궤연합조기강복대급성뇌경사환자림상료효화혈청기질금속단백매-9(MMP-9)수평적영향。방법90례급성뇌경사편탄환자，채용수궤수자표법분위대조조(n=30)、강복조(n=30)화종합조(n=30)。소유환자균접수상규약물치료，강복조채용조기강복，종합조채용기전생물반궤연합조기강복，치료2주。우치료전후채용림상신경공능결손평분(CNFDS)급개량Barthel지수(MBI)진행평정，검측혈청MMP-9수평。결과치료후，각조CNFDS평분현저하강， MBI평분현저승고(P<0.001)，종합조명현우우강복조、대조조(P<0.01)。각조혈청MMP-9수평하강，종합조하강경명현(P<0.001)。결론기전생물반궤연합조기강복가촉진신경공능적회복，궤제가능여강저혈청MMP-9수평유관。
Objective To observe the effect of electromyographic biofeedback combined with earlier rehabilitation on serum matrix me-talloproteinase-9 (MMP-9) and its clinical efficacy for patients with cerebral infarction. Methods 90 patients with acute cerebral infarction were randomly divided into control group (n=30), rehabilitation group (n=30) and combination group (n=30). All the groups received basic medication, and the rehabilitation group combined with earlier rehabilitation, the combination group with electromyographic biofeedback and earlier rehabilitation. All patients were evaluated with Clinical Neurologic Functional Default Scoring (CNFDS) and the modified Barth-el Index (MBI) before and 2 weeks after treatment. Their serum levels of MMP-9 were detected as well. Results The scores of CNFDS and MBI improved after treatment in all the groups (P<0.001), especially in the combination group (P<0.01). The levels of MMP-9 decreased more in combination group than in the rehabilitation group and the control group (P<0.001). Conclusion Electromyographic biofeedback combined with earlier rehabilitation can facilitate the recovery neural function, which may associated with the decrease of MMP-9.