CAJ | 학술논문

利用水杨酸、阿司匹林、乙酸酐和乙酸的多波长紫外光谱作为本底光谱库和样本光谱库，建立一种基于子空间夹角判据的快速定量分析阿司匹林合成体系中水杨酸和阿司匹林的方法。水杨酸、阿司匹林质量浓度范围分别在1.16～34.684，9.84～188.928μg/mL内，所测得水杨酸和阿司匹林检验集的R分别为0.9997和0.9991，RMSE分别为0.5095，2.6240μg/mL，效果优于普通波峰点最小二乘法和偏最小二乘法。水杨酸和阿司匹林的加标回收率在94.01%～106.44%之间，测定结果的相对标准偏差分别为3.45%和4.80%(n=7)。该方法可用于监测阿司匹林合成体系中的水杨酸和阿司匹林。
이용수양산、아사필림、을산항화을산적다파장자외광보작위본저광보고화양본광보고，건립일충기우자공간협각판거적쾌속정량분석아사필림합성체계중수양산화아사필림적방법。수양산、아사필림질량농도범위분별재1.16～34.684，9.84～188.928μg/mL내，소측득수양산화아사필림검험집적R분별위0.9997화0.9991，RMSE분별위0.5095，2.6240μg/mL，효과우우보통파봉점최소이승법화편최소이승법。수양산화아사필림적가표회수솔재94.01%～106.44%지간，측정결과적상대표준편차분별위3.45%화4.80%(n=7)。해방법가용우감측아사필림합성체계중적수양산화아사필림。
Ultraviolet spectroscopy of salicylic acid,aspirin,acetic anhydride and acetic acid were used as background spectrum library and standard spectral library,and a rapid analytical method based on subspace-angle was developed for the quantitative determination of salicylic acid and aspirin in synthesis systems of aspirin. The results of R in test set of salicylic acid and aspirin were 0.999 7 and 0.999 1,respectively, and RMSE were 0.509 5μg/mL and 2.624 0μg/mL,respectively,in which the concentration range of salicylic acid and aspirin were 1.16-34.684μg/mL and 9.84-188.928μg/mL,respectively. It was better than OLS and PLS. The recoveries ranged from 94.01%to 106.44%,and the relative standard deviation of determination results was 3.45%and 4.80%(n=7) for salicylic acid and aspirin,respectively. The method was suitable to monitoring salicylic acid and aspirin in synthesis systems of aspirin.