CAJ | 학술논문

目的：探讨利奈唑胺骨水泥物理和力学性能改变，以指导利奈唑胺骨水泥在治疗人工关节置换术后感染中的临床应用。方法根据在40 g骨水泥中加入不同剂量的利奈唑胺，将样本共分成8个组，每组测定5个样本，8组分别是：Ⅰ组为对照组，不加抗生素，第Ⅱ到第Ⅷ组加入抗生素的量分别为1.2、2.4、3.6、4.8、6.0、7.2及8.4g。分别测定各组面团期时间、压缩强度、弯曲模量和弯曲强度。结果各组面团时间在2′50″～3′40″之间。随着抗生素剂量的增加，面团时间也随之增加。各组的压缩强度、弯曲模量和弯曲强度均优于ISO 5833标准，且有统计学差异（ P＜0.05），Ⅱ组的压缩强度、弯曲模量和弯曲强度与对照组没有统计学差异，但高于其他各组，与其他各组间有统计学差异。而第Ⅷ组的压缩强度、弯曲模量和弯曲强度均低于其他各组，且有统计学差异。结论面团时间随着利奈唑胺剂量的增加而增加。如果利奈唑胺骨水泥用于预防性使用，则每40 g骨水泥中最多可以加入1.2g利奈唑胺，否则会影响骨水泥的强度。如果利奈唑胺骨水泥用于制作占位器，在每40 g骨水泥中最多不要加入超过7.2 g的利奈唑胺，不至于太影响骨水泥占位器的强度，但是加入的最佳剂量是多少，本系列实验的另一部分会有详细交代。
목적：탐토리내서알골수니물리화역학성능개변，이지도리내서알골수니재치료인공관절치환술후감염중적림상응용。방법근거재40 g골수니중가입불동제량적리내서알，장양본공분성8개조，매조측정5개양본，8조분별시：Ⅰ조위대조조，불가항생소，제Ⅱ도제Ⅷ조가입항생소적량분별위1.2、2.4、3.6、4.8、6.0、7.2급8.4g。분별측정각조면단기시간、압축강도、만곡모량화만곡강도。결과각조면단시간재2′50″～3′40″지간。수착항생소제량적증가，면단시간야수지증가。각조적압축강도、만곡모량화만곡강도균우우ISO 5833표준，차유통계학차이（ P＜0.05），Ⅱ조적압축강도、만곡모량화만곡강도여대조조몰유통계학차이，단고우기타각조，여기타각조간유통계학차이。이제Ⅷ조적압축강도、만곡모량화만곡강도균저우기타각조，차유통계학차이。결론면단시간수착리내서알제량적증가이증가。여과리내서알골수니용우예방성사용，칙매40 g골수니중최다가이가입1.2g리내서알，부칙회영향골수니적강도。여과리내서알골수니용우제작점위기，재매40 g골수니중최다불요가입초과7.2 g적리내서알，불지우태영향골수니점위기적강도，단시가입적최가제량시다소，본계렬실험적령일부분회유상세교대。
Objective To study the physical and mechanical properties of the linezolid-loaded bone cement in order to guide the clinical application of the linezolid-loaded bone cement in the treatment of the infection after total joint arthroplasty .Methods The specimens of the bone cement ( each of 40 g) were divided into eight groups based on the different dosage of linezolid in them ( five specimens in each group ) . Group Ⅰwith no linezolid served as the control group;group Ⅱwith 1.2 g, group Ⅲwith 2.4 g group Ⅳwith 3.6 g, group Ⅴwith 4.8 g,group Ⅵwith 6.0 g, group Ⅶ with 7.2 g,and group Ⅷwith 8.4 g.The dough time , compressive strength , bending strength and bending elastic modulus were measured .Results The dough time of all the groups was between 2′50″and 3′40″.The dough time increased with the dose of linezolid .compressive strength , bending strength and bending elastic modulus were higher than those of the ISO 5833 standard, and there was significant difference between the linezolid-loaded bone cement and the ISO 5833 standard.There was no significant difference between group Ⅱ and the control group, but the mechanical properties of group Ⅱ was higher than those of the other groups , and there were significant differences between group Ⅱand other groups .The mechanical properties of group Ⅷwas lower than those of the other groups , and there were significant differences between group Ⅷ and other groups . Conclusions The dough time increased with the dose of linezolid .If the linezolid-loaded bone cement is used to prevent infection , the maximum dose of linezolid in 40 g bone cement should be 1.2 g, otherwise it would decrease the strength of the bone cement .If the linezolid-loaded bone cement is used to make spacer , the maximum dose of linezolid in 40 g bone cement should be 7.2 g, which would not significantly affect the strength of bone cement spacer , and the optimal dose to make bone cement spacer will be discussed in another relevant experiment .