CAJ | 학술논문

目的：探讨肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。方法将本院128例患有NRDS的新生儿依据用药方案差异分为两组，其中63例给予吸痰、吸氧、机械通气等常规治疗设为对照组，其余65例在此前提下采用PS制剂气管内给药设为观察组，对比两组疗效。结果两组治疗6 h后PaO2、pH、PaO2/FiO2值均显上升趋势(P<0.05)，而PCaO2下降显著(P<0.05)；两组并发症分别为23.08%与41.27%，观察组相对较低(P<0.05)；两组住院与机械通气时间及其疗效(分别为95.38%与82.54%)对比观察组均更为理想，组间差异具有统计学意义(P<0.05)。结论将PS用于对新生儿NRDS的治疗，可明显改善其临床病症与缩短治疗时间，也有利于降低其并发症发生率和提高疗效，该法深具临床推广价值。
목적：탐토폐표면활성물질(PS)치료신생인호흡군박종합정(NRDS)적림상료효。방법장본원128례환유NRDS적신생인의거용약방안차이분위량조，기중63례급여흡담、흡양、궤계통기등상규치료설위대조조，기여65례재차전제하채용PS제제기관내급약설위관찰조，대비량조료효。결과량조치료6 h후PaO2、pH、PaO2/FiO2치균현상승추세(P<0.05)，이PCaO2하강현저(P<0.05)；량조병발증분별위23.08%여41.27%，관찰조상대교저(P<0.05)；량조주원여궤계통기시간급기료효(분별위95.38%여82.54%)대비관찰조균경위이상，조간차이구유통계학의의(P<0.05)。결론장PS용우대신생인NRDS적치료，가명현개선기림상병증여축단치료시간，야유리우강저기병발증발생솔화제고료효，해법심구림상추엄개치。
Objective To study clinical value of lung surface active substance treating neonatal respiratory distress syndrome. Methods Choosing 128 newborns with NRDS in our hospital and dividing them into two groups according to drug difference, of which 63 cases were given conventional treatment, such as sputum aspiration, oxygen, mechanical ventilation, as control group, the remaining 65 cases under the premise on PS preparation endotracheal medication as observation group. Curative effect of two groups were compared. Results PaO2, pH value, PaO2/FiO2 in the two groups after treatment 6 hours showed rising trend (P<0.05), while PCaO2 decreased significantly (P<0.05);complications in the two groups were 23.08%and 41.27%, relatively low in observation group (P<0.05);in the two groups in the hospital with mechanical ventilation time and its curative effect (95.38%, 82.54%respectively) compared to observation group were more ideal, with obviously difference between groups (P<0.05). Conclusion Applying PS to the treatment of neonatal NRDS, can obviously improve the clinical symptoms and shorten the treatment time, and also can reduce the incidence of complications and improve curative effect, so it is worthy of clinical promotion.