南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2013年
11期
1704-1708
,共5页
刘欣%王节%张舜欣%林倩
劉訢%王節%張舜訢%林倩
류흔%왕절%장순흔%림천
年龄%前列腺癌%前列腺特异性抗原
年齡%前列腺癌%前列腺特異性抗原
년령%전렬선암%전렬선특이성항원
age%prostate cancer%prostate-specific antigen
目的：探讨前列腺特异性抗原（PSA）在不同年龄段临床无前列腺癌人群中的参考值范围，以提高PSA在前列腺癌筛查中的诊断准确性。方法自2010年4月~2011年10月来我院进行正常健康查体的1611例成年男性为参与者。所有参与者均接受前列腺特异性抗原抽血检查、肛门指检（DRE）及经直肠超声（TRUS）检查。以上三项检查任何两项出现异常者，行前列腺穿刺活检。最终共有1572位无前列腺癌者纳入本研究。按年龄分为5组，40~49岁、50~59岁、60~69岁、70~79岁、≥80岁。结果中位数（95%分位数）分别为：40~49岁为0.506（1.565），50~59岁为1.04（2.920），60~69岁为1.16（4.113），70~79岁为1.34（5.561），80岁以上为2.975（7.285）。按年龄从低至高各组的25%分位数至75%分位数分别为0.343~0.923，0.663~1.580，0.693~2.203，0.789~2.368、1.188~4.295。前列腺特异性抗原与年龄呈正相关（r=0.314，P<0.001）。结论在前列腺癌筛查时，对不同年龄段的人使用不同的血清PSA参考值范围，能提高其诊断准确率，但不同民族和地区应选择适合本地区人群的血清PSA参考值。
目的：探討前列腺特異性抗原（PSA）在不同年齡段臨床無前列腺癌人群中的參攷值範圍，以提高PSA在前列腺癌篩查中的診斷準確性。方法自2010年4月~2011年10月來我院進行正常健康查體的1611例成年男性為參與者。所有參與者均接受前列腺特異性抗原抽血檢查、肛門指檢（DRE）及經直腸超聲（TRUS）檢查。以上三項檢查任何兩項齣現異常者，行前列腺穿刺活檢。最終共有1572位無前列腺癌者納入本研究。按年齡分為5組，40~49歲、50~59歲、60~69歲、70~79歲、≥80歲。結果中位數（95%分位數）分彆為：40~49歲為0.506（1.565），50~59歲為1.04（2.920），60~69歲為1.16（4.113），70~79歲為1.34（5.561），80歲以上為2.975（7.285）。按年齡從低至高各組的25%分位數至75%分位數分彆為0.343~0.923，0.663~1.580，0.693~2.203，0.789~2.368、1.188~4.295。前列腺特異性抗原與年齡呈正相關（r=0.314，P<0.001）。結論在前列腺癌篩查時，對不同年齡段的人使用不同的血清PSA參攷值範圍，能提高其診斷準確率，但不同民族和地區應選擇適閤本地區人群的血清PSA參攷值。
목적：탐토전렬선특이성항원（PSA）재불동년령단림상무전렬선암인군중적삼고치범위，이제고PSA재전렬선암사사중적진단준학성。방법자2010년4월~2011년10월래아원진행정상건강사체적1611례성년남성위삼여자。소유삼여자균접수전렬선특이성항원추혈검사、항문지검（DRE）급경직장초성（TRUS）검사。이상삼항검사임하량항출현이상자，행전렬선천자활검。최종공유1572위무전렬선암자납입본연구。안년령분위5조，40~49세、50~59세、60~69세、70~79세、≥80세。결과중위수（95%분위수）분별위：40~49세위0.506（1.565），50~59세위1.04（2.920），60~69세위1.16（4.113），70~79세위1.34（5.561），80세이상위2.975（7.285）。안년령종저지고각조적25%분위수지75%분위수분별위0.343~0.923，0.663~1.580，0.693~2.203，0.789~2.368、1.188~4.295。전렬선특이성항원여년령정정상관（r=0.314，P<0.001）。결론재전렬선암사사시，대불동년령단적인사용불동적혈청PSA삼고치범위，능제고기진단준학솔，단불동민족화지구응선택괄합본지구인군적혈청PSA삼고치。
Objective To determine the age-related normal ranges of serum prostate-specific antigen (PSA) level in men free of prostate cancer in Beijing. Methods Form April 2010 to October 2011, 1611 healthy men undergoing routine physical examinations in our hospital were enrolled and received examinations with serum PSA test, digital rectal examination and transrectal ultrasound. The men with abnormalities in any two of the three examinations were referred to a prostate biopsy. The men with normal results in any two of the examinations or with a negative biopsy finding were defined as men without prostate cancer. Men with a prior history of prostate cancer/surgery or with urinary tract infection/obstruction were excluded. Results A total of 1572 men without prostate cancer were finally included in this study and stratified into 5 age groups, namely 40 to 49, 50 to 59, 60 to 69, 70 to 79, and older than 80 years groups. The median PSA values (95th percentile ranges) of these age groups were 0.506 (1.565), 1.04 (2.920), 1.16 (4.113), 1.34 (5.561), and 2.975(7.285), respectively, and the 25th to 75th percentiles were 0.343 to 0.923, 0.663 to 1.580, 0.693 to 2.203, 0.789 to 2.368, and 1.188 to 4.295, respectively. The serum PSA value was positively correlated with age (r=0.314, P<0.001). Conclusion Using the age-related reference ranges for PSA can increase the sensitivity for screening prostate cancer in younger men and decrease the biopsy rate in elderly patients.
