CAJ | 학술논문

目的：建立华北城市地区成人肺通气功能的预计值方程式。方法对来自华北城市地区进行过基础体检符合健康成人条件的1200例（男性600例，女性600例）体检者测定用力肺活量（FVC）、第1秒用力呼气容积（FEV1）等5个常用肺通气指标，通过多元逐步回归求得各指标预计方程式，并与ECSC、Knudson等常用预计方程式比较预测值和实测值差异。结果肺功能指标中FVC、FEV1、FEF25%、FEF75%存在性别差异，FEV1/FVC无性别差异。多元逐步回归分析，男、女性肺功能指标FVC、FEV1、FEF 25%、FEF 25%均与身高呈正相关，与年龄呈负相关，而FEV1/FVC与身高及年龄均呈负相关，五项指标与体质量均无明显相关性。建立的肺功能指标的预计方程式，与其他预计方程式比较，本方程预计值与实测值差异最小。结论本研究建立的肺通气功能的预计方程式较适用于华北城市地区成人。
목적：건립화북성시지구성인폐통기공능적예계치방정식。방법대래자화북성시지구진행과기출체검부합건강성인조건적1200례（남성600례，녀성600례）체검자측정용력폐활량（FVC）、제1초용력호기용적（FEV1）등5개상용폐통기지표，통과다원축보회귀구득각지표예계방정식，병여ECSC、Knudson등상용예계방정식비교예측치화실측치차이。결과폐공능지표중FVC、FEV1、FEF25%、FEF75%존재성별차이，FEV1/FVC무성별차이。다원축보회귀분석，남、녀성폐공능지표FVC、FEV1、FEF 25%、FEF 25%균여신고정정상관，여년령정부상관，이FEV1/FVC여신고급년령균정부상관，오항지표여체질량균무명현상관성。건립적폐공능지표적예계방정식，여기타예계방정식비교，본방정예계치여실측치차이최소。결론본연구건립적폐통기공능적예계방정식교괄용우화북성시지구성인。
Objective To establish predictive equations of lung function for adults in urban areas in north China. Methods A survey was conducted in 600 male and 600 female healthy adults in the urban areas in north China. Five flow-volume test parameters were measured including forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). Stepwise multiple regression was carried out to establish the predicative equations for the parameters for male and female adults separately. The predicted values from these equations and those from other commonly used equations (such as ECCS equation and Knudson equation) were compared with the actual measurements in pulmonary function tests. Results Four flow-volume test parameters, namely FVC, FEV1, 25% forced expiratory flow (FEF25%), and FEF75%, showed obvious differences between the male and female adults, while FEV1/FVC was not correlated with gender. Multiple regression analysis showed that FVC, FEV1, FEF25%and FEF75%were positively correlated with height and negatively with age, and FEV1/FVC was negatively correlated with both height and age. The parameters were not affected by body weight. The predicted values from our equations were closer to the actual measurements than those calculated from other equations. Conclusion The equations we established are more appropriate than the generally used equations for predicting lung functions in adults in north China urban areas.