CAJ | 학술논문

目的：探讨 AuroraA、CyclinD1、CyclinB1和Bcl-2在膀胱移行细胞瘤（BTCC）中的表达及其意义。方法用免疫组织化学的方法检测 AuroraA、CyclinD1、CyclinB1和Bcl-2在56例BTCC和15例正常膀胱组织中的表达情况，并分析其与 BTCC临床病理因素的关系。结果 BTCC组织AuroraA阳性率为51．8％（29/56），高于正常膀胱组织的13．3％（2/15）（P＜0．01）；Cy-clinD1阳性率为46．4％（26/56），高于正常膀胱组织的6．7％（1/15）（P＜0．01）；CyclinB1阳性率为75．0％（42/56），高于正常膀胱组织的33．3％（5/15）（P＜0．01）；Bcl-2的表达为62．5％（35/56），高于正常膀胱组织的6．7％（1/15）（P＜0．01）。AuroraA、Cy-clinB1和Bcl-2阳性率与BTCC的病理分级呈正相关，但是 CyclinD1随病理分级增加阳性率下降。AuroraA阳性率与临床分期呈正相关，CyclinD1则呈负相关；CyclinB1和 Bcl-2阳性率与临床分期无关。AuroraA阳性率与 CyclinD1（r＝0．508，P＜0．01）、CyclinB1（r＝0．594，P＜0．01）和Bcl-2（r＝－0．535，P＜0．01）阳性率明显相关。结论 AuroraA可能影响 CyclinD1、CyclinB1和Bcl-2的表达。
목적：탐토 AuroraA、CyclinD1、CyclinB1화Bcl-2재방광이행세포류（BTCC）중적표체급기의의。방법용면역조직화학적방법검측 AuroraA、CyclinD1、CyclinB1화Bcl-2재56례BTCC화15례정상방광조직중적표체정황，병분석기여 BTCC림상병리인소적관계。결과 BTCC조직AuroraA양성솔위51．8％（29/56），고우정상방광조직적13．3％（2/15）（P＜0．01）；Cy-clinD1양성솔위46．4％（26/56），고우정상방광조직적6．7％（1/15）（P＜0．01）；CyclinB1양성솔위75．0％（42/56），고우정상방광조직적33．3％（5/15）（P＜0．01）；Bcl-2적표체위62．5％（35/56），고우정상방광조직적6．7％（1/15）（P＜0．01）。AuroraA、Cy-clinB1화Bcl-2양성솔여BTCC적병리분급정정상관，단시 CyclinD1수병리분급증가양성솔하강。AuroraA양성솔여림상분기정정상관，CyclinD1칙정부상관；CyclinB1화 Bcl-2양성솔여림상분기무관。AuroraA양성솔여 CyclinD1（r＝0．508，P＜0．01）、CyclinB1（r＝0．594，P＜0．01）화Bcl-2（r＝－0．535，P＜0．01）양성솔명현상관。결론 AuroraA가능영향 CyclinD1、CyclinB1화Bcl-2적표체。
Objective To investigate the expression of AuroraA,CyclinD1,CyclinB1 and Bcl-2 in BTCC with regard to the clini-cal significance.Methods Expressions of AuroraA,CyclinD1 ,CyclinB1 and Bcl-2 were detected by immmunohistochemical staining in 5 6 cases of BTCC and 1 5 cases of normal bladder tissues as controls.The relevance between the expressions of AuroraA,Cy-clinD1 ,CyclinB1 and Bcl-2 and the clinical pathology of the patients of BTCC were studied.Results Immmunohistochemical stai-ning demonstrated that the positive rate of AuroraA,CyclinD1,CyclinB1 and Bcl-2 respectively was 51.8%(29/56),46.4%(26/56),75.0%(42/56)and 62.5%(35/56)in BTCC,which is significantly higher than normal bladder tissues as 13.3%(2/15),6.7%(1/15),33.3%(5/15)and 6.7%(1/15)(P<0.01)respectively.The positive rate of AuroraA,CyclinB1 and Bcl-2 were significant-ly positive correlated with the grade of the tumor(P<0.05),but CyclinD1 with negative correlation.And no correlation was found between The positive rate of CyclinB1、Bcl-2 and clinical staging,but AuroraA with positive correlation and Bcl-2 with negative one. There was a significantly verse relationship between the positive rate of AuroraA and CyclinD1(r=0.508,P<0.01),but a positive correlation between AuroraA and CyclinB1(r=0.594,P<0.01)、Bcl-2(r=0.535,P<0.01).Conclusion AuroraA could exert in-fluence on the expression of CyclinD1、CyclinB1 and Bcl-2.