CAJ | 학술논문

目的：分析云南省西双版纳地区傣族和哈尼族人群INFγrs2430561位点基因多态性的分布情况。方法运用基质辅助激光解析电离飞行时间质谱技术检测傣族和哈尼族人群IFNγ rs2430561位点基因型及等位基因频率。结果（1）傣族与哈尼族人群 IFNγ rs2430561位点 AA/TA/TT 基因型频率分别为0.060/0.380/0.560和0.000/0.310/0.690，A/T等位基因频率分别为0.250/0.750和0.155/0.845，两民族基因型和等位基因分布频率显著不同，差异有统计学意义(χ2分别为8.128和5.588，P值分别为0.014和0.025)。结论 IFNγrs2430561多态性位点基因型和等位基因分布频率具有民族、种族差异。
목적：분석운남성서쌍판납지구태족화합니족인군INFγrs2430561위점기인다태성적분포정황。방법운용기질보조격광해석전리비행시간질보기술검측태족화합니족인군IFNγ rs2430561위점기인형급등위기인빈솔。결과（1）태족여합니족인군 IFNγ rs2430561위점 AA/TA/TT 기인형빈솔분별위0.060/0.380/0.560화0.000/0.310/0.690，A/T등위기인빈솔분별위0.250/0.750화0.155/0.845，량민족기인형화등위기인분포빈솔현저불동，차이유통계학의의(χ2분별위8.128화5.588，P치분별위0.014화0.025)。결론 IFNγrs2430561다태성위점기인형화등위기인분포빈솔구유민족、충족차이。
Objection To investigate the distribution of IFNγgene in rs2430561 polymorphism between Dai and Hani minority population in Xishuangbanna district ,Yunnan province. Methods Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry was used to study the genotypes and allele frequencies distributions of IFNγ gene in rs2430561 polymorphism in Dai and Hani minority population. Results The genotype and allele frequencies of rs2430561 polymorphisms had statistical difference between Dai and Hani minority population (χ2=8.128 and 5.588, P=0.014 and 0.025). Conclusion The genotypes and allele frequencies distribution of IFNγgene in rs2430561 polymorphism is different in different national and ethnic populations.