中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
15期
7074-7078
,共5页
谈瑶曦%陈波%许伟%吴剑卿
談瑤晞%陳波%許偉%吳劍卿
담요희%진파%허위%오검경
肺肿瘤%肿瘤干细胞%Meta分析%CD133
肺腫瘤%腫瘤榦細胞%Meta分析%CD133
폐종류%종류간세포%Meta분석%CD133
Lung neoplasms%Neoplastic stem cells%Meta-analysis%CD133
目的：通过Meta分析的方法综合评价CD133与肺癌患者临床病理特征关系。方法计算机检索Pubmed、Embase和CNKI，纳入公开发表涉及CD133表达与肺癌临床病理特征的中英文文献，使用Stata 12.0统计学软件对符合条件的文献进行分析。结果共获取文献15篇（英文7篇、中文8篇），1102例患者。Meta分析结果CD133表达在临床分期Ⅰ、Ⅱ期与Ⅲ期之间无显著性差异（pooled OR＝0.782，95%CI＝0.435～1.406，P＝0.411）。CD133表达在腺癌与非腺癌之间无显著性差异（pooled OR＝0.97，95%CI＝0.71～1.33， P＝0.86）。CD133表达在肺癌低分化与高分化差异有统计学意义（pooled OR＝1.66，95%CI＝1.15～2.40， P＝0.006）；CD133表达在肺癌淋巴结转移与非淋巴结转移差异有统计学意义（pooled OR＝2.98，95%CI＝2.04～4.35，P＜0.001）。结论 CD133阳性与肺癌组织低分化相关，且发生淋巴结转移可能性高。
目的：通過Meta分析的方法綜閤評價CD133與肺癌患者臨床病理特徵關繫。方法計算機檢索Pubmed、Embase和CNKI，納入公開髮錶涉及CD133錶達與肺癌臨床病理特徵的中英文文獻，使用Stata 12.0統計學軟件對符閤條件的文獻進行分析。結果共穫取文獻15篇（英文7篇、中文8篇），1102例患者。Meta分析結果CD133錶達在臨床分期Ⅰ、Ⅱ期與Ⅲ期之間無顯著性差異（pooled OR＝0.782，95%CI＝0.435～1.406，P＝0.411）。CD133錶達在腺癌與非腺癌之間無顯著性差異（pooled OR＝0.97，95%CI＝0.71～1.33， P＝0.86）。CD133錶達在肺癌低分化與高分化差異有統計學意義（pooled OR＝1.66，95%CI＝1.15～2.40， P＝0.006）；CD133錶達在肺癌淋巴結轉移與非淋巴結轉移差異有統計學意義（pooled OR＝2.98，95%CI＝2.04～4.35，P＜0.001）。結論 CD133暘性與肺癌組織低分化相關，且髮生淋巴結轉移可能性高。
목적：통과Meta분석적방법종합평개CD133여폐암환자림상병리특정관계。방법계산궤검색Pubmed、Embase화CNKI，납입공개발표섭급CD133표체여폐암림상병리특정적중영문문헌，사용Stata 12.0통계학연건대부합조건적문헌진행분석。결과공획취문헌15편（영문7편、중문8편），1102례환자。Meta분석결과CD133표체재림상분기Ⅰ、Ⅱ기여Ⅲ기지간무현저성차이（pooled OR＝0.782，95%CI＝0.435～1.406，P＝0.411）。CD133표체재선암여비선암지간무현저성차이（pooled OR＝0.97，95%CI＝0.71～1.33， P＝0.86）。CD133표체재폐암저분화여고분화차이유통계학의의（pooled OR＝1.66，95%CI＝1.15～2.40， P＝0.006）；CD133표체재폐암림파결전이여비림파결전이차이유통계학의의（pooled OR＝2.98，95%CI＝2.04～4.35，P＜0.001）。결론 CD133양성여폐암조직저분화상관，차발생림파결전이가능성고。
Objective To evaluate the association between CD133 expression and clinical-pathological features of lung cancer, with a meta-analysis. Methods Articles investigating the association between CD133 and clinicopathological features of lung cancer were identified by an electronic search on Pubmed, Embase and CNKI. The meta-analysis was performed using the statistical software STATA version 12.0. Results 1102 patients from 15 studies were included. Comparing stage Ⅰ-Ⅱ with stage Ⅲ, there was no association between positive CD133 expression and tumor stage(pooled OR=0.782, 95% CI=0.435-1.406, P=0.411). There was no significant relationship between positivity CD133 expression and histology type (adenocarcinoma vs. non-adenocarcinoma) with pooled OR=0.97, 95% CI=0.71-1.33, P=0.86. Compared poor differentiation with well differentiation, positive CD133 expression was significantly correlated with poor differentiation (pooled OR=1.66, 95% CI=1.15-2.40, P=0.006). Positive CD133 expression was associated with nodal status (pooled OR=2.98, 95% CI=2.04-4.35, P<0.001). Conclusion CD133 play an important role in lung cancer, positive CD133 expression is significantly associated with differentiation and lymph node metastasis.
