CAJ | 학술논문

目的：探索经阴道建立宫内节育器（IUD）避孕大鼠模型的造模效果。方法以100只 SD已生育大鼠为受试对象，随机分为经阴道组、开腹组、经阴道假手术组、开腹假手术组、空白对照组，各组再随机设立亚组1（合笼）、亚组2（不合笼），10只/亚组。亚组1于造模后第22天开腹观察大鼠避孕率和胚胎计数；亚组2于造模后第3、10、16天，观察大鼠造模前后的一般状态，并进行旷场实验。结果经阴道与开腹放置IUD，避孕率均为100%，且对侧宫腔内胚胎数差异无显著性（P＞0.05)。较之开腹造模，经阴道造模对大鼠的一般状况影响小。经阴道造模前后大鼠中央格停留时间、水平穿越格数、直立次数、修饰次数的比较差异均无统计学意义（P＞0.05)。结论经阴道造模大鼠能为 IUD 节育副反应研究提供有效的动物模型。
목적：탐색경음도건립궁내절육기（IUD）피잉대서모형적조모효과。방법이100지 SD이생육대서위수시대상，수궤분위경음도조、개복조、경음도가수술조、개복가수술조、공백대조조，각조재수궤설립아조1（합롱）、아조2（불합롱），10지/아조。아조1우조모후제22천개복관찰대서피잉솔화배태계수；아조2우조모후제3、10、16천，관찰대서조모전후적일반상태，병진행광장실험。결과경음도여개복방치IUD，피잉솔균위100%，차대측궁강내배태수차이무현저성（P＞0.05)。교지개복조모，경음도조모대대서적일반상황영향소。경음도조모전후대서중앙격정류시간、수평천월격수、직립차수、수식차수적비교차이균무통계학의의（P＞0.05)。결론경음도조모대서능위 IUD 절육부반응연구제공유효적동물모형。
Objective To investigate contraceptive rat model with the intrauterine device(IUD) transvaginal placement. Methods 100 SD female rats were divided into transvaginal operation group, abdomen-incision group, transvaginal sham operation group, abdomen-incision sham operation group and blank control group. Each group includes 20 rats. The groups were further randomly set up subgroup 1 and subgroup 2, which were both include 10 rats. The pregnancy rate and embryo counts would be observed in subgroup 1 on the twenty-second day after modeling. Before making the model and the 3, 10, 16 days after modeling, the rats of each group were performed the open field test. Results IUD contraception rate were all 100% between transvaginal operation group to abdomen-incision group. The difference of contralateral intrauterine embryo number in two groups had no significant meaning(P>0.05). Influence of the general situation of transvaginal operation group was much lower than that of abdomen-incision group. Before and after making models, each index of open field test had no significant difference(P>0.05). Conclusion IUD rat with transvaginal modeling method provide a valid animal model for IUD side effects study.