中国医疗前沿
中國醫療前沿
중국의료전연
CHINA HEALTHCARE INNOVATION
2013年
18期
33-35
,共3页
王艳华%张惠妍%苏文利%朱文献%王毅鑫
王豔華%張惠妍%囌文利%硃文獻%王毅鑫
왕염화%장혜연%소문리%주문헌%왕의흠
危重型多发伤%血必净%乌司他丁%全身炎症反应综合症%脓毒症
危重型多髮傷%血必淨%烏司他丁%全身炎癥反應綜閤癥%膿毒癥
위중형다발상%혈필정%오사타정%전신염증반응종합증%농독증
Critical type multiple trauma%Xuebijing injuction%Ulinastatin%Systemic inflammatory response syndrome%Sepsis
目的:探讨血必净联合乌司他丁在治疗危重型多发伤合并重度感染的临床疗效。方法将本院2009年3月-2012年3月间70例危重型多发伤病例随机分为常规治疗对照组和血必净联合乌司他丁治疗实验组各35例。观察临床症状和测定肝肾功能、血清IL-1β、IL-6、TNF-α、降钙素原(PCT)和血清C-反应蛋白(hs-CRP)。结果治疗后48h和120h两组血清IL-1β、IL-6、TNF-α、PCT和hs-CRP均有降低(P<0.05),实验组较对照组下降更明显(P<0.05)。结论血必净联合乌司他丁应用能有效降低危重型多发伤合并重度感染和脓毒症患者的炎症反应。
目的:探討血必淨聯閤烏司他丁在治療危重型多髮傷閤併重度感染的臨床療效。方法將本院2009年3月-2012年3月間70例危重型多髮傷病例隨機分為常規治療對照組和血必淨聯閤烏司他丁治療實驗組各35例。觀察臨床癥狀和測定肝腎功能、血清IL-1β、IL-6、TNF-α、降鈣素原(PCT)和血清C-反應蛋白(hs-CRP)。結果治療後48h和120h兩組血清IL-1β、IL-6、TNF-α、PCT和hs-CRP均有降低(P<0.05),實驗組較對照組下降更明顯(P<0.05)。結論血必淨聯閤烏司他丁應用能有效降低危重型多髮傷閤併重度感染和膿毒癥患者的炎癥反應。
목적:탐토혈필정연합오사타정재치료위중형다발상합병중도감염적림상료효。방법장본원2009년3월-2012년3월간70례위중형다발상병례수궤분위상규치료대조조화혈필정연합오사타정치료실험조각35례。관찰림상증상화측정간신공능、혈청IL-1β、IL-6、TNF-α、강개소원(PCT)화혈청C-반응단백(hs-CRP)。결과치료후48h화120h량조혈청IL-1β、IL-6、TNF-α、PCT화hs-CRP균유강저(P<0.05),실험조교대조조하강경명현(P<0.05)。결론혈필정연합오사타정응용능유효강저위중형다발상합병중도감염화농독증환자적염증반응。
Objective To explore the effects and clinical value of Xuebijing injection and Ulinastatin injection on severe infection and sepsis of patients with critical type multiple trauma. Methods 70 patients of critical type multiple trauma were randomly divided into two groups: treatment group(35 cases) and control group(35 cases). Clinical effects were observed, and the hepatic and renal functions, IL-1β, IL-6, TNF-α, PCT and hs-CRP. Results After treatment of 48 hours and 120 hours, the serum levels of IL-6, TNF-α, PCT and hs-CRP were reduced significantly in two groups(P<0.05); the degree of reduction were more significant in treatment groups than those in control groups (P<0.05). Conclusion The application of Xuebijing injection and Ulinastatin injection could significantly improve the inflammatory response in patients with critical type multiple trauma.