中国医疗前沿
中國醫療前沿
중국의료전연
CHINA HEALTHCARE INNOVATION
2013年
18期
1-2
,共2页
阻塞性睡眠呼吸暂停综合症%胰岛素抵抗%血清脂连素%稳态模型法
阻塞性睡眠呼吸暫停綜閤癥%胰島素牴抗%血清脂連素%穩態模型法
조새성수면호흡잠정종합증%이도소저항%혈청지련소%은태모형법
Obstructive sleep apnea syndrome%Insulin resistance%Serum adiponectin%State model method
目的：研究阻塞性睡眠呼吸暂停综合症(OSAS)患者胰岛素抵抗同血清脂连素、抵抗素水平的关系。方法采用两两匹配的病例对照研究，选择体重、年龄相当的老年OSAS患者50例作为病例组，另外选取35例单纯打鼾组作为对照，使用多导睡眠仪进行监测，并使用放射免疫分析法、酶联免疫法测定研究对象的血清脂连素、抵抗素水平。采用稳态模型法(HOMA)计算IR指数。结果病例组的血清脂连素水平低于对照组，而甘油三酯水平，空腹胰岛素(FINS)、HOMA-IR、抵抗素水平均高于对照组。经Logistic多元回归分析显示血糖指数、体重指数、呼吸暂停低通气指数、脂连素、抵抗素均是OSAS患者发生胰岛素抵抗的独立危险因素。结论 OSAS患者病情进一步加重与脂连素、抵抗素有关，而发展为胰岛素抵抗可能同空腹血糖、空腹胰岛素、体重指数、呼吸暂停通气指数均有关系。通过控制上述指标可能降低OSAS患者并发IR的风险。
目的：研究阻塞性睡眠呼吸暫停綜閤癥(OSAS)患者胰島素牴抗同血清脂連素、牴抗素水平的關繫。方法採用兩兩匹配的病例對照研究，選擇體重、年齡相噹的老年OSAS患者50例作為病例組，另外選取35例單純打鼾組作為對照，使用多導睡眠儀進行鑑測，併使用放射免疫分析法、酶聯免疫法測定研究對象的血清脂連素、牴抗素水平。採用穩態模型法(HOMA)計算IR指數。結果病例組的血清脂連素水平低于對照組，而甘油三酯水平，空腹胰島素(FINS)、HOMA-IR、牴抗素水平均高于對照組。經Logistic多元迴歸分析顯示血糖指數、體重指數、呼吸暫停低通氣指數、脂連素、牴抗素均是OSAS患者髮生胰島素牴抗的獨立危險因素。結論 OSAS患者病情進一步加重與脂連素、牴抗素有關，而髮展為胰島素牴抗可能同空腹血糖、空腹胰島素、體重指數、呼吸暫停通氣指數均有關繫。通過控製上述指標可能降低OSAS患者併髮IR的風險。
목적：연구조새성수면호흡잠정종합증(OSAS)환자이도소저항동혈청지련소、저항소수평적관계。방법채용량량필배적병례대조연구，선택체중、년령상당적노년OSAS환자50례작위병례조，령외선취35례단순타한조작위대조，사용다도수면의진행감측，병사용방사면역분석법、매련면역법측정연구대상적혈청지련소、저항소수평。채용은태모형법(HOMA)계산IR지수。결과병례조적혈청지련소수평저우대조조，이감유삼지수평，공복이도소(FINS)、HOMA-IR、저항소수평균고우대조조。경Logistic다원회귀분석현시혈당지수、체중지수、호흡잠정저통기지수、지련소、저항소균시OSAS환자발생이도소저항적독립위험인소。결론 OSAS환자병정진일보가중여지련소、저항소유관，이발전위이도소저항가능동공복혈당、공복이도소、체중지수、호흡잠정통기지수균유관계。통과공제상술지표가능강저OSAS환자병발IR적풍험。
Objective To study the changes of Serllm adiponectin and resistin levels in old patients with OSAS and the relationship of adiponeetin and resistin with insulin resistance(IR). Methods Using two matched case-control study, choose the weight, age, quite in elderly patients with OSAS 50 cases as a group, in addition to choose simple snoring group 35 cases as a contrast, using multiple guide apparatus to monitor the sleep, and use the radiation immunoassay, enzyme-linked immune method to determine the object of study of serum lipid even element, resistin level. By using the steady state model method(HOMA) index calculation of IR. Results Cases of serum lipid levels lower than the control group, and triglyceride levels, fasting insulin(FINS), HOMA IR, resistin levels were higher than the control group. After Logistic multivariate regression analysis showed that glycemic index, body mass index, apnea hypoventilation index, grease even element, resistin are independent risk factors of insulin resistance in patients with OSAS. Conclusion OSAS patients further related to fat even element, resistin, and for the development of insulin resistance may be with fasting blood glucose, fasting insulin, body mass index, apnea ventilation index have relations. By controlling the above indicators may reduce the risk of OSAS patients complicated with IR.
