CAJ | 학술논문

目的：对慢性丙型肝炎患者不同时期血清sCR1浓度进行检测研究，探讨慢性丙型肝炎sCR1浓度变化与该病发生、发展及预后的关系，探索慢性丙型肝炎发生和发展的有效检测指标。结果：①慢性丙型肝炎轻度，中度、重度及肝硬化病人血清 sCR1浓度均显著高于正常人群，且慢性丙型肝炎随着病情的发展程度而逐渐升高，重度大于中度，中度大于轻度。②慢性丙型肝炎三组的测定值明显差异性。③肝硬化组随着Child-Pugh分级的升高，其sCR1浓度也随着升高。结论：慢性丙型肝炎病人血清 sCR1浓度的变化与肝功能损伤程度密切相关，随着肝硬化程度的加重其浓度也相应的升高，该指标可作为慢性丙型肝炎患者病情严重程度、判断病情发展及预后的重要参考指标。
목적：대만성병형간염환자불동시기혈청sCR1농도진행검측연구，탐토만성병형간염sCR1농도변화여해병발생、발전급예후적관계，탐색만성병형간염발생화발전적유효검측지표。결과：①만성병형간염경도，중도、중도급간경화병인혈청 sCR1농도균현저고우정상인군，차만성병형간염수착병정적발전정도이축점승고，중도대우중도，중도대우경도。②만성병형간염삼조적측정치명현차이성。③간경화조수착Child-Pugh분급적승고，기sCR1농도야수착승고。결론：만성병형간염병인혈청 sCR1농도적변화여간공능손상정도밀절상관，수착간경화정도적가중기농도야상응적승고，해지표가작위만성병형간염환자병정엄중정도、판단병정발전급예후적중요삼고지표。
Objective:To detect and research for different periods of chronic hepatitis C patients in serum concentrations of sCR1. To investigate the relationship between the changes of sCR1 concentration and the occurrence, development and prognosis of chronic hepatitis C. To explore effective detection index of the occurrence and development. Results: ①Chronic hepatitis C with mild, moderate, severe and the concentration of serum sCR1 in patients with liver cirrhosis were higher than the normal population, and chronic hepatitis C and increased gradually with the development of the severity of the greater than moderate, severe, moderate than the mild.②Chronic hepatitis C were determined in three group were significantly different. ③Cirrhotic patients with Child-Pugh score increased, the sCR1 concentration also increased. Conclusion:Chronic hepatitis C patients with serum sCR1 concentration changes related to the degree of liver dysfunction. With the aggravation of liver cirrhosis concentration also increased, the index can be used as the condition of patients with chronic hepatitis C, judging the severity of an important reference index for disease development and prognosis.