CAJ | 학술논문

目的：检测颅内肿瘤患者外周血液细胞免疫功能，探讨细胞免疫功能与WHO颅内肿瘤分级的关系，为颅内肿瘤的综合治疗提供依据。方法回顾研究2010年8月至2013年5月我科收治的79例颅内手术患者，应用流式细胞仪进行术前外周血液细胞免疫功能的检测，根据术后病理诊断明确肿瘤WHO分级。用Spearman等级相关分析法分析细胞免疫功能与肿瘤WHO分级的相关关系。结果最终纳入研究共57例患者，经Spearman等级相关分析显示，CD3+、CD4+/CD8+、CD8+、CD16+CD56+及CD19+与颅内肿瘤WHO分级无相关（P跃0.05），CD4+与颅内肿瘤WHO分级呈低度负相关（r=-0.292，P<0.05）。结论颅内肿瘤WHO分级与细胞免疫功能无明显相关关系，有待进一步研究。
목적：검측로내종류환자외주혈액세포면역공능，탐토세포면역공능여WHO로내종류분급적관계，위로내종류적종합치료제공의거。방법회고연구2010년8월지2013년5월아과수치적79례로내수술환자，응용류식세포의진행술전외주혈액세포면역공능적검측，근거술후병리진단명학종류WHO분급。용Spearman등급상관분석법분석세포면역공능여종류WHO분급적상관관계。결과최종납입연구공57례환자，경Spearman등급상관분석현시，CD3+、CD4+/CD8+、CD8+、CD16+CD56+급CD19+여로내종류WHO분급무상관（P약0.05），CD4+여로내종류WHO분급정저도부상관（r=-0.292，P<0.05）。결론로내종류WHO분급여세포면역공능무명현상관관계，유대진일보연구。
Objective To investigate whether the cellular immunity status of intracranial tumors correlates with their WHO classifi-cation. Methods In this retrospective analysis of 79 patients operated on for intracranial tumors between August 2010 and May 2013,flow cytometry was used to assess levels of various T cell populations in the tumor tissue,and the WHO classification of the tis-sue was determined by postoperative pathology.Possible correlations between T cell populations and WHO classification were investi-gated using Spearman’s rank correlation. Results In the final analysis of 57 patients,levels of T cells positive for CD3+,CD4+/CD8+, CD8+,CD16+CD56+and CD19+did not correlate with WHO classification.However,the level of CD4+T cells negatively correlated with WHO classification(P<0.05). Conclusions In intracranial tumors,cellular immunity status does not significantly correlate with WHO classification.