CAJ | 학술논문

目的：通过研究鼻腔局部冲洗和应用激素对变应性鼻炎的影响，探讨治疗变应性鼻炎的恰当方式。方法临床方面采用视觉模拟评分量表（VAS）和迷你型鼻结膜炎生活质量问卷（MiniRQLQ）评估健康对照组及各实验组临床症状的改变，实验室方面采用瑞典Pharmacia UniCAP 100型免疫荧光定量分析系统检测健康对照组及各实验组血清中屋尘螨特异性IgE（sIgE）和嗜酸性粒细胞阳离子蛋白（ECP）的含量的改变。结果单纯鼻腔冲洗组（A组）和局部激素溶液冲洗组（D组）无论是临床方面还是实验室方面评估都没有显著性改变，而单纯鼻喷激素组（B组）和鼻喷激素联合冲洗组（C组）两方面均有统计学差异，并且后两组间比较无显著性差异。结论单纯鼻喷激素或鼻喷激素联合冲洗是治疗变应性鼻炎的恰当方式，单纯鼻腔冲洗或局部激素溶液冲洗在治疗变应性鼻炎方面只能作为辅助手段。
목적：통과연구비강국부충세화응용격소대변응성비염적영향，탐토치료변응성비염적흡당방식。방법림상방면채용시각모의평분량표（VAS）화미니형비결막염생활질량문권（MiniRQLQ）평고건강대조조급각실험조림상증상적개변，실험실방면채용서전Pharmacia UniCAP 100형면역형광정량분석계통검측건강대조조급각실험조혈청중옥진만특이성IgE（sIgE）화기산성립세포양리자단백（ECP）적함량적개변。결과단순비강충세조（A조）화국부격소용액충세조（D조）무론시림상방면환시실험실방면평고도몰유현저성개변，이단순비분격소조（B조）화비분격소연합충세조（C조）량방면균유통계학차이，병차후량조간비교무현저성차이。결론단순비분격소혹비분격소연합충세시치료변응성비염적흡당방식，단순비강충세혹국부격소용액충세재치료변응성비염방면지능작위보조수단。
Objective To investigate the influence of local irrigation and hormone treatment on allergic rhinitis and to confirm the appropriate therapies of allergic rhinitis.Methods Using the visual analogue scale (VAS) and Mini Juniper Rhinoconjunctivitis QoL Questionnaire (MiniRQLQ) to assess the symptoms among the control group and the various intervention groups in clinic and applying quantitative analysis of immunofluorescent to detect the contents of house dust mite specific IgE (sIgE) and eosinophil cationic protein (ECP) with Pharmacia UniCAP 100 system among the control group and the various intervention groups in experiment.Results TThere were no significant differences both in the single nasal irrigation group (A group) and in the local hormone solution irrigation group (D group) whether in clinic or in experiment.However,statistical significant differences appeared in the single nasal spray group (B group) and in the combined treatment of nasal irrigation and spray (C group).Furthermore,C group was not better than B group.Conclusion Single nasal spray and combined treatment of nasal irrigation and spray are all the appropriate therapies of allergic rhinitis.Single nasal irrigation and local hormone solution irrigation may only play a role in adjunct treatment of allergic rhinitis.