CAJ | 학술논문

目的：探讨联合应用同型半胱氨酸（HCY）和D-二聚体（D-Dimer）对肝癌血栓前状态预测的临床应用价值。方法选取50例原发性肝癌患者（肝癌组），30例肝硬化患者（肝硬化组），30例健康对照组，检测血清HCY、血浆D-Dimer的水平，应用 ROC曲线分析其对肝癌血栓前状态的预测价值。结果肝癌组与肝硬化组、健康对照组比较，血清 HCY、D-Dimer水平均明显升高（P＜0．05）；肝硬化组与健康对照组比较，血清D-Dimer水平明显升高（P＜0．05），而HCY差异无统计学意义（P＝0．912）。原发性肝癌患者的 HCY、D-Dimer与两者联合检测在ROC曲线下的面积分别为0．902、0．846、0．941。HCY、D-Dimer对原发性肝癌血栓前状态的临床预测临界点分别为13．28μmol/L、1451 ng/mL。结论 HCY和D-Dimer可以作为原发性肝癌血栓前状态的辅助诊断指标，两者联合应用可以提高对原发性肝癌血栓前状态的检出率。
목적：탐토연합응용동형반광안산（HCY）화D-이취체（D-Dimer）대간암혈전전상태예측적림상응용개치。방법선취50례원발성간암환자（간암조），30례간경화환자（간경화조），30례건강대조조，검측혈청HCY、혈장D-Dimer적수평，응용 ROC곡선분석기대간암혈전전상태적예측개치。결과간암조여간경화조、건강대조조비교，혈청 HCY、D-Dimer수평균명현승고（P＜0．05）；간경화조여건강대조조비교，혈청D-Dimer수평명현승고（P＜0．05），이HCY차이무통계학의의（P＝0．912）。원발성간암환자적 HCY、D-Dimer여량자연합검측재ROC곡선하적면적분별위0．902、0．846、0．941。HCY、D-Dimer대원발성간암혈전전상태적림상예측림계점분별위13．28μmol/L、1451 ng/mL。결론 HCY화D-Dimer가이작위원발성간암혈전전상태적보조진단지표，량자연합응용가이제고대원발성간암혈전전상태적검출솔。
Objective To explore the predictive value of homocysteine (HCY)combined with D-Dimer in the prethrombotic state of primary hepatocarcinoma (PHC) .Methods 50 cases of primary liver cancer ,30 cases of hepat-ic sclerosis and 30 cases of healthy human were selected ,and the levels of HCY and D-Dimer were detected .The pre-dictive value was evaluated by ROC curve .Results The HCY and D-Dimer in the PHC group were significantly higher than that in hepatic sclerosis and control group(P<0 .05) .The D-Dimer level was significantly higher in he-patic sclerosis group than that in healthy human(P<0 .05) ,while there was no significance of HCY between the he-patic sclerosis and the control group(P=0 .912) .The areas under ROC curve of HCY ,D-Dimer and the joint detec-tion of the two indexes were 0 .902 ,0 .846 and 0 .941 ,respectively .The clinical predictive critical points of HCY and D-Dimer in PHC with prethrombotic state were 13 .28μmol/L and 1 451 ng/mL ,respectively .Conclusion The com-bination of the HCY and D-Dimer could predict the prethrombotic state of the primary hepatocarcinoma .