CAJ | 학술논문

骨是乳腺癌最常见且最优先的远部转移部位。乳腺癌细胞增殖转移到骨引起溶骨性和成骨性骨损伤，其发生是多个因素共同作用的结果，包括骨微环境提供的生长支持、乳腺癌细胞对骨微环境的适应能力，以及它们之间复杂的相互作用。骨微环境内细胞包括成骨细胞、破骨细胞、基质细胞、造血干细胞、内皮细胞等，这些细胞可产生多种细胞因子，促进乳腺癌细胞生长和乳腺癌骨转移进展；乳腺癌细胞也会释放多种因子，影响骨微环境内细胞及细胞因子，加重对骨的破坏。
골시유선암최상견차최우선적원부전이부위。유선암세포증식전이도골인기용골성화성골성골손상，기발생시다개인소공동작용적결과，포괄골미배경제공적생장지지、유선암세포대골미배경적괄응능력，이급타문지간복잡적상호작용。골미배경내세포포괄성골세포、파골세포、기질세포、조혈간세포、내피세포등，저사세포가산생다충세포인자，촉진유선암세포생장화유선암골전이진전；유선암세포야회석방다충인자，영향골미배경내세포급세포인자，가중대골적파배。
Breast cancers preferentially metastasize to bone, which generally cause osteolytic and osteoblastic lesions. The crosstalk between metastatic breast cancer cells and bone microenvironment plays a central role in the development and pro-gression of bone metastases. Bone is rich in cell types and cytokine that make it a predominant environment for breast cancer cells growth. Once breast cancer cells enter the bone microenvironment,they can secrete factors that act on bone cells and contribute to the bone destruction.