CAJ | 학술논문

目的：探讨利培酮联合丙戊酸治疗伴有冲动和攻击行为的男性精神分裂症患者的疗效和安全性。方法对74例伴有冲动和攻击行为的男性精神分裂症患者随机分成研究组（利培酮联合丙戊酸钠治疗）37例，对照组（单用利培酮治疗）37例，疗程6w。结果两组在治疗后PANSS评分及MOAS评分均较治疗前显著下降(均P<0.05)，研究组PANSS总分、阳性症状分及MOAS总分较对照组下降显著(P<0．05)；两组不良反应相当，无统计学差异(P>0.05)。结论利培酮联合丙戊酸治疗伴有冲动和攻击行为的男性精神分裂症患者起效快，可增加疗效，安全性好。
목적：탐토리배동연합병무산치료반유충동화공격행위적남성정신분렬증환자적료효화안전성。방법대74례반유충동화공격행위적남성정신분렬증환자수궤분성연구조（리배동연합병무산납치료）37례，대조조（단용리배동치료）37례，료정6w。결과량조재치료후PANSS평분급MOAS평분균교치료전현저하강(균P<0.05)，연구조PANSS총분、양성증상분급MOAS총분교대조조하강현저(P<0．05)；량조불량반응상당，무통계학차이(P>0.05)。결론리배동연합병무산치료반유충동화공격행위적남성정신분렬증환자기효쾌，가증가료효，안전성호。
Objective to study the risperidone with valproic acid therapy with impulse and at ack the ef icacy and safety of male patients with schizophrenia. Methods:74cases with impulse and aggressive behavior of male schizophrenia patients were randomly divided into research group (risperidone combined valproate treatment)37cases,control group (risperidone therapy)37 cases, course of six weeks. Results:two groups after treatment PANSS scores and MOAS score was a significant reduction in the (al P<0.05),the team PANSS score,positive symptom and total scores of MOAS down significantly compared with control group (P<0.05);Two groups of adverse reactions, no statistical dif erence(P>0. 05) conclusion:risperidone with valproic acid therapy with impulse and aggressive behavior of male schizophrenia patients work fast,can increase the curative ef ect,good safety.