CAJ | 학술논문

骨细胞是骨组织中含量最丰富、存活时间最长的细胞。通过细胞突触，骨细胞保持了彼此间以及与骨基质表面其他类型细胞的联系，构成了动态的、功能活跃的骨稳态细胞调控网络。骨细胞可以直接感受机械刺激，将其转化为生化信号并传递到其他细胞，同时，骨细胞还可分泌多种功能蛋白，协同指导骨重建。骨细胞是骨组织中信号传递的桥梁枢纽，也是体内矿物平衡和胞外微环境的重要调节者。完整的骨细胞网络结构是维持骨组织正常功能的关键。
골세포시골조직중함량최봉부、존활시간최장적세포。통과세포돌촉，골세포보지료피차간이급여골기질표면기타류형세포적련계，구성료동태적、공능활약적골은태세포조공망락。골세포가이직접감수궤계자격，장기전화위생화신호병전체도기타세포，동시，골세포환가분비다충공능단백，협동지도골중건。골세포시골조직중신호전체적교량추뉴，야시체내광물평형화포외미배경적중요조절자。완정적골세포망락결구시유지골조직정상공능적관건。
Osteocytes are the most abundant and longest-surviving cells in bone tissue .Through cell syn-apses, osteocytes keep in contact with each other and with other types of cells on bone matrix surface , constituting a dynamic and active cell regulation network in bone homeostasis .Osteocytes can directly sense mechanical stimulus , translate it into biochemical signals and send to other cells .In addition , os-teocytes can mediate bone remodeling by secreting a variety of cytokines .In summary , it is indicated that osteocytes play a crucial role in skeletal mechanotransduction , and they also act as the major regulator re-sponsible for skeletal metabolic balance and microenvironment homeostasis .The integrated network of os-teocytes is essential to maintain the normal function of bone tissue .