CAJ | 학술논문

巨噬细胞迁移抑制因子（ macrophage migration inhibitory factor ， MIF）是一类具有独特结构的多效免疫调节细胞因子，具有类似趋化因子的功能。自1966年被发现以来，MIF在人体内的功能，尤其是它在固有免疫、免疫细胞招募和炎症反应等方面有了很多的研究进展。虽然名字被称为巨噬细胞迁移抑制因子，但其实MIF还具有促炎症反应，促进细胞定向迁移，拮抗糖皮质激素，抑制细胞凋亡，促进其他促炎因子释放等功能。因此与多种具有炎症反应过程的疾病如动脉粥样硬化、自身免疫病、癌症和代谢性疾病等相关。本文就MIF的分子通路、功能、相关疾病及临床应用等方面的研究进展进行综述。
거서세포천이억제인자（ macrophage migration inhibitory factor ， MIF）시일류구유독특결구적다효면역조절세포인자，구유유사추화인자적공능。자1966년피발현이래，MIF재인체내적공능，우기시타재고유면역、면역세포초모화염증반응등방면유료흔다적연구진전。수연명자피칭위거서세포천이억제인자，단기실MIF환구유촉염증반응，촉진세포정향천이，길항당피질격소，억제세포조망，촉진기타촉염인자석방등공능。인차여다충구유염증반응과정적질병여동맥죽양경화、자신면역병、암증화대사성질병등상관。본문취MIF적분자통로、공능、상관질병급림상응용등방면적연구진전진행종술。
Macrophage migration inhibitory factor ( MIF) is a pleiotropic immunoregulator which has a u-nique structure and a chemokine-like function .Since it was dicovered in 1966 , the functions of MIF have been indicated , such as non-specific immunity , the inflammatory cell recruitment , and inflammatory re-action .In addition to its eponymic activity , MIF also has a proinflammatory function and promotes the di-rected migration and recruitment of leukocytes into infectious and inflammatory sites;it also has functions such as anti-glucocorticoids , anti-apoptosis , and promoting the release of other cytokines .As a result , MIF plays an important role in atherosclerosis , autoimmune diseases , cancer , and metabolic diseases .In this review , we will discuss the molecular pathway , function , related diseases and clinical application of MIF.