天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
6期
585-587
,共3页
癌,非小细胞肺%raf激酶类%肿瘤侵润%肿瘤转移%非小细胞肺癌%Snail%Raf激酶抑制蛋白
癌,非小細胞肺%raf激酶類%腫瘤侵潤%腫瘤轉移%非小細胞肺癌%Snail%Raf激酶抑製蛋白
암,비소세포폐%raf격매류%종류침윤%종류전이%비소세포폐암%Snail%Raf격매억제단백
carcinoma,non-small-cell lung%raf kinases%neoplasm invasiveness%neoplasm metastasis%NSCLC%snail%Raf kinase inhibitor protein
目的：检测非小细胞肺癌（NSCLC）组织中Snail和Raf激酶抑制蛋白(RKIP)的表达情况。方法采用免疫组织化学方法检测124例NSCLC及67例癌旁正常肺组织中Snail和RKIP的表达情况，比较临床病理特征与Snail和RKIP阳性表达率的关系，分析Snail和RKIP的相关关系。结果 Snail蛋白在肺癌中表达率为79.03%，高于正常肺组织的19.40%（χ2=63.538，P<0.01）；RKIP在肺癌中的表达率为36.29%，低于正常肺组织的77.61%（χ2=29.716， P<0.01）。两者的表达水平均与肺癌的分化程度、TNM分期、淋巴结转移及术后生存时间有关；Snail与RKIP的蛋白表达水平呈负相关（P<0.05）。结论 Snail高表达与RKIP低表达可能是NSCLC侵袭转移的重要生物学标志，可作为NSCLC的预后指标。
目的：檢測非小細胞肺癌（NSCLC）組織中Snail和Raf激酶抑製蛋白(RKIP)的錶達情況。方法採用免疫組織化學方法檢測124例NSCLC及67例癌徬正常肺組織中Snail和RKIP的錶達情況，比較臨床病理特徵與Snail和RKIP暘性錶達率的關繫，分析Snail和RKIP的相關關繫。結果 Snail蛋白在肺癌中錶達率為79.03%，高于正常肺組織的19.40%（χ2=63.538，P<0.01）；RKIP在肺癌中的錶達率為36.29%，低于正常肺組織的77.61%（χ2=29.716， P<0.01）。兩者的錶達水平均與肺癌的分化程度、TNM分期、淋巴結轉移及術後生存時間有關；Snail與RKIP的蛋白錶達水平呈負相關（P<0.05）。結論 Snail高錶達與RKIP低錶達可能是NSCLC侵襲轉移的重要生物學標誌，可作為NSCLC的預後指標。
목적：검측비소세포폐암（NSCLC）조직중Snail화Raf격매억제단백(RKIP)적표체정황。방법채용면역조직화학방법검측124례NSCLC급67례암방정상폐조직중Snail화RKIP적표체정황，비교림상병리특정여Snail화RKIP양성표체솔적관계，분석Snail화RKIP적상관관계。결과 Snail단백재폐암중표체솔위79.03%，고우정상폐조직적19.40%（χ2=63.538，P<0.01）；RKIP재폐암중적표체솔위36.29%，저우정상폐조직적77.61%（χ2=29.716， P<0.01）。량자적표체수평균여폐암적분화정도、TNM분기、림파결전이급술후생존시간유관；Snail여RKIP적단백표체수평정부상관（P<0.05）。결론 Snail고표체여RKIP저표체가능시NSCLC침습전이적중요생물학표지，가작위NSCLC적예후지표。
Objective To detect Snail and Raf kinase inhibitor protein (RKIP) expressions in NSCLC (Non-Small Cell Lung Cancer) and their relationship with the pathological characteristics of tumor. Methods Immunohistochemistry was used to detect Snail and RKIP expression in 124 NSCLC samples and 67 paraneoplastic normal lung tissue samples. Snail and RKIP positive expression rates were compared upon clinicopathologic characteristics. Correlation of Snail expres-sion with RKIP expression was also analyzed. Results Positive expression rate of Snail was 79.03%in lung cancer, which is higher than that in normal lung tissue 19.40%(χ2=63.538, P<0.01);positive expression rate of RKIP was 36.29%in lung cancer which is lower than that in normal lung tissue 77.61%(χ2=29.716,P<0.01), Snail and RKIP expressions are corre-lated with tumor differentiation, TNM stage, lymph node metastasis and postoperative survival time ( P<0.05, respectively) . Snail protein expression is negatively correlated with RKIP expression in NSCLC (P<0.05). Conclusion High Snail ex-pression and the low RKIP expression might be important biological markers for invasion and metastasis of NSCLC, which might be used as important prognostic indicators in NSCLC.
