CAJ | 학술논문

目的：研究肿瘤相关糖抗原sTn在子宫内膜癌、子宫内膜非典型增生、良性子宫病变患者子宫内膜组织中的表达情况，分析其与子宫内膜癌患者手术病理分期、病理分级等的关系及临床意义。方法采用免疫组化方法检测sTn在子宫内膜癌组（93例，包括子宫内膜样癌80例，浆液性乳头状癌10例，透明细胞癌3例）、子宫内膜非典型增生组（50例）、子宫良性病变组（50例）子宫内膜组织中的表达。结果 sTn在子宫内膜癌组的阳性率为73.1%，与子宫内膜非典型增生组（32%）和良性子宫病变组（14%）差异均有统计学意义（P<0.017）；sTn在子宫内膜样癌组织中表达率为78.8%，明显高于在其他组子宫内膜组织中的表达（P<0.008）；sTn在低分化的子宫内膜癌中的表达率显著高于高分化的子宫内膜癌（P<0.017）；在肿瘤浸润深度＞1/2肌层组的子宫内膜癌组织中的阳性表达率高于≤1/2肌层组（P＜0.05）；在有、无淋巴结转移组的子宫内膜癌组织中的阳性表达率差异无统计学意义（P＞0.05）。结论sTn的表达可能在子宫内膜癌的发生、发展中起一定的作用。
목적：연구종류상관당항원sTn재자궁내막암、자궁내막비전형증생、량성자궁병변환자자궁내막조직중적표체정황，분석기여자궁내막암환자수술병리분기、병리분급등적관계급림상의의。방법채용면역조화방법검측sTn재자궁내막암조（93례，포괄자궁내막양암80례，장액성유두상암10례，투명세포암3례）、자궁내막비전형증생조（50례）、자궁량성병변조（50례）자궁내막조직중적표체。결과 sTn재자궁내막암조적양성솔위73.1%，여자궁내막비전형증생조（32%）화량성자궁병변조（14%）차이균유통계학의의（P<0.017）；sTn재자궁내막양암조직중표체솔위78.8%，명현고우재기타조자궁내막조직중적표체（P<0.008）；sTn재저분화적자궁내막암중적표체솔현저고우고분화적자궁내막암（P<0.017）；재종류침윤심도＞1/2기층조적자궁내막암조직중적양성표체솔고우≤1/2기층조（P＜0.05）；재유、무림파결전이조적자궁내막암조직중적양성표체솔차이무통계학의의（P＞0.05）。결론sTn적표체가능재자궁내막암적발생、발전중기일정적작용。
Objective To investigate the expression and clinical significance of tumor-associated carbohydrate anti-gen sTn in endometrium from patients with atypical hyperplasia of endometrium, endometrial carcinoma and benign the uter-ine lesion. And to analyze the association between sTn and the pathologic stage and grade of endometrial carcinoma. Meth-ods sTn was detected by immunohistochemistry in 193 patient samples, including 93 subjects with endometrial carcinoma, 50 subjects with atypical hyperplasia of endometrium and 50 subjects with benign uterine lesions. Results The positive sTn rate in endometrial carcinoma group was 73.1%,which was significantly different from that in atypical hyperplasia endo-metrium group (32%) and that in benign uterine lesion group (14%), (P<0.017). sTn positive rate in patients with endometri-al carcinoma was 78.8%which is higher than that in patients with other diseases (P<0.008 ). The positive rate of sTn in pa-tients with poorly differentiated endometrial carcinoma was significantly higher than that in patients with highly differentiat-ed endometrial carcinoma (P<0.017). The positive rate of sTn in tissues of tumor infiltration with depth of more than half of myometrial was significantly higher than in tissues of tumor infiltration with depth of equal or less than half of myometrial (P<0.05). But there was no significant difference in sTn positive rate between the endometrial carcinoma groups with and without lymph node metastasis (P>0.05). Conclusion sTn may play a role in the tumorigenesis and development of endo-metrial carcinoma.