CAJ | 학술논문

胃癌是威胁人类健康的常见恶性肿瘤之一.近年来,手术方式的改革和放化疗方案的优化仍远未达到降低胃癌发病率和病死率的目标.转化医学作为一种全新的研究模式,已经悄然出现在各个临床课题之中,效果斐然.本文就转化医学的定义及发展、胃癌分子标志物以及胃癌的药物治疗展开讨论,阐述转化医学在胃癌治疗中的作用,探讨其可行性.我们认为,转化医学的介入或可改变现今科研与临床严重脱节的现状,提高胃癌患者的术前检出率以及手术后辅助治疗的有效率,最终改善胃癌患者预后,提高其生存率.
위암시위협인류건강적상견악성종류지일.근년래,수술방식적개혁화방화료방안적우화잉원미체도강저위암발병솔화병사솔적목표.전화의학작위일충전신적연구모식,이경초연출현재각개림상과제지중,효과비연.본문취전화의학적정의급발전、위암분자표지물이급위암적약물치료전개토론,천술전화의학재위암치료중적작용,탐토기가행성.아문인위,전화의학적개입혹가개변현금과연여림상엄중탈절적현상,제고위암환자적술전검출솔이급수술후보조치료적유효솔,최종개선위암환자예후,제고기생존솔.
Gastric cancer is one of the most common malignant tumors which is a great threat to human health.In recent years,the reform of surgical mordalities and the optimization of radiation and chemotherapy is still far from reducing morbidity and mortality of gastric cancer.As a new research pattern,translational medicine has emerged in various clinical subjects,which leads to remarkable effects.In this paper,the definition and development of translational medicine,molecular markers and drug treatment of gastric cancer will be discussed and the feasibility of translational medicine in the treatment of gastric cancer will be explained.In our opinion,the intervention of translational medicine could change the current situation that scientific researches is severely disconnected with clinical practice and increase the detection rate of gastric cancer and the effective rate of adjuvant therapy after surgery to improve the prognosis of patients with gastric cancer.