CAJ | 학술논문

2型糖尿病是最常见的威胁公众健康的慢性病之一.传统治疗控制血糖的方法效果较差.胃旁路术在治疗病态性肥胖的同时,可以快速、有效、长期地缓解其并发的2型糖尿病,但其机制目前仍不明确.十二指肠空肠旁路术是胃旁路术的一种改良术式,主要用来研究胃旁路术治疗2型糖尿病的机制,对非病态性肥胖的2型糖尿病患者的临床治疗也取得了一些初步的研究结果.本文对十二指肠空肠旁路术治疗2型糖尿病的效果及机制进行总结,以期对胃旁路术改善糖代谢的机制进行进一步的阐述,并对代谢手术治疗糖尿病的临床应用提供理论依据.
2형당뇨병시최상견적위협공음건강적만성병지일.전통치료공제혈당적방법효과교차.위방로술재치료병태성비반적동시,가이쾌속、유효、장기지완해기병발적2형당뇨병,단기궤제목전잉불명학.십이지장공장방로술시위방로술적일충개량술식,주요용래연구위방로술치료2형당뇨병적궤제,대비병태성비반적2형당뇨병환자적림상치료야취득료일사초보적연구결과.본문대십이지장공장방로술치료2형당뇨병적효과급궤제진행총결,이기대위방로술개선당대사적궤제진행진일보적천술,병대대사수술치료당뇨병적림상응용제공이론의거.
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases and public health problems.Roux-en-Y gastric bypass (RYGB) can rapidly,effectively and sustainably improve glycemic control in morbidly obese patients with T2DM.However,the mechanisms of glycemic control after RYGB are still unclear now.Duodenal-jejunal bypass (DJB) is an improved RYGB sparing intact stomach,which is mainly used to investigate the mechanisms of RYGB to treat T2DM.DJB has also been used to treat non-obese T2DM patients.In the present article,we review the results and mechanisms of DJB to treat T2DM on the basis of the previous studies to further elucidate the mechanisms of RYGB in the management of T2DM.