CAJ | 학술논문

目的：观察凯时注射液联合托拉塞米对高血压引起的慢性肾功能衰竭的疗效。方法选择在该科住院由高血压引起的慢性肾功能衰竭患者66例，随机分为观察组（凯时联合托拉塞米组）和对照组（单用凯时组），每组33例。两组在常规治疗基础上，治疗组给予凯时注射液10μg加入0.9％氯化钠注射液10 ml中缓慢静推，托拉塞米注射液20 mg加入0.9％氯化钠注射液10 ml中缓慢静推；对照组给予凯时注射液10μg加入0.9％氯化钠注射液10 ml中缓慢静推，14 d为1个疗程。治疗前后检测24 h尿蛋白定量、血清肌酐（SCr）、血尿素氮（BUN）。结果两组治疗前后SCr、BUN和24 h尿蛋白比较差异均有统计学意义（P＜0.01）；两组治疗后三项指标均降低（P＜0.01），但观察组降幅大于对照组（P＜0.01）。结论凯时注射液与托拉塞米联合应用对高血压引起的慢性肾功能衰竭有良好的疗效。联合应用比单用凯时疗效更好。
목적：관찰개시주사액연합탁랍새미대고혈압인기적만성신공능쇠갈적료효。방법선택재해과주원유고혈압인기적만성신공능쇠갈환자66례，수궤분위관찰조（개시연합탁랍새미조）화대조조（단용개시조），매조33례。량조재상규치료기출상，치료조급여개시주사액10μg가입0.9％록화납주사액10 ml중완만정추，탁랍새미주사액20 mg가입0.9％록화납주사액10 ml중완만정추；대조조급여개시주사액10μg가입0.9％록화납주사액10 ml중완만정추，14 d위1개료정。치료전후검측24 h뇨단백정량、혈청기항（SCr）、혈뇨소담（BUN）。결과량조치료전후SCr、BUN화24 h뇨단백비교차이균유통계학의의（P＜0.01）；량조치료후삼항지표균강저（P＜0.01），단관찰조강폭대우대조조（P＜0.01）。결론개시주사액여탁랍새미연합응용대고혈압인기적만성신공능쇠갈유량호적료효。연합응용비단용개시료효경호。
Objective To investigate the clinical effects of kaishi injection combined with torasemide in the treatment of patients with hypertensive chronic renal failure .Methods Sixty-six patients with hypertensive chronic renal failure were enrolled and randomly divided into observation group and control group ,thirty-three cases for each group.Patients in the observation group were treated with kaishi injection combined with torasemide ,the patients in the control group were treated with kaishi injection only .After fourteen days′treatment, SCr, BUN and 24h urinary protein were measured .Results After treatment the levels of SCr , BUN and 24 h urinary protein decreased in two groups, but the reduction of above indexes in the research group was much lower than the control group (P<0.01). Conclusion Kaishi injection combined with torasemide has more positive effect in the treatment of hypertensive chronic renal failure than kaishi injection only .