CAJ | 학술논문

目的：探讨血浆前脑利钠肽（proBNP）对肝硬化心肌病的判断价值。方法对38例肝硬化患者（ LC组）和20名健康体检者（ CG 组），用ELISA法测定血浆proBNP水平，并行心电图检查。比较两组proBNP水平及心电图改变（ QTc、QTd、QTcd和Pd）的差异；对肝硬化患者，分析心电图改变与 CTP 积分、MELD评分、proBNP的关系。结果 LC组proBNP水平为（228.0±83.4） fmol/ml，显著高于CG组（127.4±21.1）fmol/ml。 LC组QTc、QTd、QTcd、Pd分别为（446.9±28.0）ms1/2、（36.4±6.6）ms、（40.6±9.0）ms1/2、（22.8±4.8）ms，均显著长于CG组（417.2±21.5）ms1/2、（29.6±4.9）ms、（31.1±4.9）ms1/2、（19.0±4.1）ms，且与CTP、MELD、proBNP水平呈正相关。结论肝硬化患者存在心肌受损，血浆proBNP可较好地反映肝硬化心肌病病情。
목적：탐토혈장전뇌리납태（proBNP）대간경화심기병적판단개치。방법대38례간경화환자（ LC조）화20명건강체검자（ CG 조），용ELISA법측정혈장proBNP수평，병행심전도검사。비교량조proBNP수평급심전도개변（ QTc、QTd、QTcd화Pd）적차이；대간경화환자，분석심전도개변여 CTP 적분、MELD평분、proBNP적관계。결과 LC조proBNP수평위（228.0±83.4） fmol/ml，현저고우CG조（127.4±21.1）fmol/ml。 LC조QTc、QTd、QTcd、Pd분별위（446.9±28.0）ms1/2、（36.4±6.6）ms、（40.6±9.0）ms1/2、（22.8±4.8）ms，균현저장우CG조（417.2±21.5）ms1/2、（29.6±4.9）ms、（31.1±4.9）ms1/2、（19.0±4.1）ms，차여CTP、MELD、proBNP수평정정상관。결론간경화환자존재심기수손，혈장proBNP가교호지반영간경화심기병병정。
Objective To investigate the value of plasma pro B-type natriuretic peptide level in diagnosis of cirrhotic cardiomyopathy(CCM).Methods Plasma proBNP levels,the changes on ECG(QTc,QTd,QTcd and Pd) were measured and evaluated in 38 patients with cirrhosis and 20 healthy controls , and compared between the two groups.In patients with cirrhosis , the association between the changes on ECG and CTP score ,MELD score,proBNP levels were analyzed .Results ProBNP was significantly higher in patients with cirrhosis ( 228.0 ±83.4 ) fmol/ml than in healthy controls(127.4 ±21.1 )fmol/ml.And in patients with cirrhosis,the changes on ECG, QTc、QTd, QTcd and Pd, were (446.9 ±28.0)ms1/2,(36.4 ±6.6)ms,(40.6 ±9.0)ms1/2,(22.8 ±4.8)ms respectively and significantly increased compared with healthy subjects (417.2 ±21.5)ms1/2,(29.6 ±4.9)ms,(31.1 ±4.9)ms1/2, (19.0 ±4.1)ms, and positively related to CTP score,MELD score and proBNP level.Conclusion The plasma level of proBNP was valuable for diagnosis of CCM ,and correlated with the severity of CCM .