中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2013年
12期
1151-1153
,共3页
张政%翁敬锦%杨嘉珍%陈甲信%王勇利%覃扬达%孙金杰%覃颖%李冰%司勇锋
張政%翁敬錦%楊嘉珍%陳甲信%王勇利%覃颺達%孫金傑%覃穎%李冰%司勇鋒
장정%옹경금%양가진%진갑신%왕용리%담양체%손금걸%담영%리빙%사용봉
辐射损伤%皮肤损伤%辐射防护剂
輻射損傷%皮膚損傷%輻射防護劑
복사손상%피부손상%복사방호제
Radiation injuries%Skin damage%Radiation protection agents
目的：观察加味三黄汤冷冻液预防鼻咽癌颈部急性放射性皮肤损伤的临床疗效。方法31例接受放射治疗的首诊鼻咽癌患者入组研究，颈部右侧涂抹加味三黄汤冷冻液为用药组，颈部左侧为空白对照组。结果颈部右侧皮肤出现损伤的时间为（15.26±6.15）d，颈部左侧皮肤出现损伤时间为（11.14±5.28）d，差异有统计学意义（ P＜0.05）。用药组和对照组的皮肤反应发生率分别为74.19％（23/31）和87.10％（27/31），差异无统计学意义（P＞0.05）；两组皮肤损伤程度差异有统计学意义（P＜0.05）。用药组和对照组重度疼痛发生率分别为35.48％和70.97％，差异有统计学意义（ P＜0.05）。皮肤反应用药组为13.04％（3/23）出现于照射20 Gy以前，对照组为59.26％（16/27），差异有统计学意义（P＜0.05）。结论加味三黄汤冷冻液可预防鼻咽癌颈部放射性皮炎的发生，具有降低皮损程度的作用，值得进一步研究。
目的：觀察加味三黃湯冷凍液預防鼻嚥癌頸部急性放射性皮膚損傷的臨床療效。方法31例接受放射治療的首診鼻嚥癌患者入組研究，頸部右側塗抹加味三黃湯冷凍液為用藥組，頸部左側為空白對照組。結果頸部右側皮膚齣現損傷的時間為（15.26±6.15）d，頸部左側皮膚齣現損傷時間為（11.14±5.28）d，差異有統計學意義（ P＜0.05）。用藥組和對照組的皮膚反應髮生率分彆為74.19％（23/31）和87.10％（27/31），差異無統計學意義（P＞0.05）；兩組皮膚損傷程度差異有統計學意義（P＜0.05）。用藥組和對照組重度疼痛髮生率分彆為35.48％和70.97％，差異有統計學意義（ P＜0.05）。皮膚反應用藥組為13.04％（3/23）齣現于照射20 Gy以前，對照組為59.26％（16/27），差異有統計學意義（P＜0.05）。結論加味三黃湯冷凍液可預防鼻嚥癌頸部放射性皮炎的髮生，具有降低皮損程度的作用，值得進一步研究。
목적：관찰가미삼황탕냉동액예방비인암경부급성방사성피부손상적림상료효。방법31례접수방사치료적수진비인암환자입조연구，경부우측도말가미삼황탕냉동액위용약조，경부좌측위공백대조조。결과경부우측피부출현손상적시간위（15.26±6.15）d，경부좌측피부출현손상시간위（11.14±5.28）d，차이유통계학의의（ P＜0.05）。용약조화대조조적피부반응발생솔분별위74.19％（23/31）화87.10％（27/31），차이무통계학의의（P＞0.05）；량조피부손상정도차이유통계학의의（P＜0.05）。용약조화대조조중도동통발생솔분별위35.48％화70.97％，차이유통계학의의（ P＜0.05）。피부반응용약조위13.04％（3/23）출현우조사20 Gy이전，대조조위59.26％（16/27），차이유통계학의의（P＜0.05）。결론가미삼황탕냉동액가예방비인암경부방사성피염적발생，구유강저피손정도적작용，치득진일보연구。
Objective To observe the clinical effect of frozen jiaweisanhuangtang in the prevention of acute radiation-induced neck skin damage in patients with nasopharyngeal carcinoma .Methods Thirty-one patients with nasopharyngeal carcinoma undergoing radiotherapy were enrolled in the study , frozen jiaweisanhuangtang were applied to right-neck as treatment group , and left-neck were as a blank control group .Results The time of occurrence of skin injury at right-neck was (15.26 ±6.15)days, and the time at left-neck was (11.14 ±5.28)days, the difference was statistically significant ( P<0.05 ) .The incidence of skin damage in treatment group and control group were 74.19%(23/31) and 87.10%(27/31) respectively, the difference was not statistically significant (P>0.05);thus difference of degree of skin damage between two groups was statistically significant ( P<0.05 ) .The incidence of moderate to severe pain in treatment group and control group were 35.48%and 70.97%respectively , the difference was statistically significant ( P<0.05 ) .Thirteen point zero four percent of patients in treatment group showed skin damage before total 20 Gy of irradiation, and 59.26%(16/27) of patients showed in the control group , the difference was statistically significant ( P<0.05 ) .Conclusion The frozen jiaweisanhuangtang can effectively prevent the occur-rence of acute radiation-induced neck skin damage , especially reduce the degree of skin damage , and it is worth fur-ther study .
