CAJ | 학술논문

目的：了解广西南宁地区壮族人群中ABO和RhD血型分布及基因频率，为指导本地区制定合理的采血、储血计划以及防治新生儿ABO溶血病提供科学依据。方法随机整群抽取南宁市的隆安、武鸣、上林三县壮族无关个体4527名进行ABO、RhD血型鉴定和分析。结果广西南宁地区壮族ABO血型分布特征为O＞B＞A＞AB；其基因频率p（ A）＝0.1312、q（ B）＝0.1761、r（ O）＝0.6927。 ABO血型表型分布及基因频率相对稳定，符合Hardy-Weinberg平衡法则。民族指数为0.7636。南宁地区壮族人群Rh（ D）阳性频率为99.8012％，Rh（ D）阴性率为0.1988％，d基因频率为0.044587。结论南宁地区壮族人群Rh（ D）阴性发生率较低；其ABO血型分布显示南方地区少数民族特征，即O基因频率较高，A基因频率偏低。
목적：료해엄서남저지구장족인군중ABO화RhD혈형분포급기인빈솔，위지도본지구제정합리적채혈、저혈계화이급방치신생인ABO용혈병제공과학의거。방법수궤정군추취남저시적륭안、무명、상림삼현장족무관개체4527명진행ABO、RhD혈형감정화분석。결과엄서남저지구장족ABO혈형분포특정위O＞B＞A＞AB；기기인빈솔p（ A）＝0.1312、q（ B）＝0.1761、r（ O）＝0.6927。 ABO혈형표형분포급기인빈솔상대은정，부합Hardy-Weinberg평형법칙。민족지수위0.7636。남저지구장족인군Rh（ D）양성빈솔위99.8012％，Rh（ D）음성솔위0.1988％，d기인빈솔위0.044587。결론남저지구장족인군Rh（ D）음성발생솔교저；기ABO혈형분포현시남방지구소수민족특정，즉O기인빈솔교고，A기인빈솔편저。
Objective To investigate the distribution of RhD and ABO blood type and gene frequencies in Zhuang nationality in Nanning , Guangxi in order to provide the evidence for making reasonable blood management plan and prevention of ABO hemolytic disease of newborn .Methods The ABO and RhD blood groups of 4 527 unre-lated individuals were analyzed by randomized sampling .Results Blood type distribution showed O >B>A>AB, the genetic frequency included p (A)=0.1312, q(B)=0.1761 and r(O)=0.6927.The distribution of ABO blood type and genetic frequency met Hardy-Weinberg.Nationality index was 0.7636.The rate of positive RhD was 99.8012%,the rate of negative Rh ( D) was 0.1988% and the rate of d gene was 0.044587 .Conclusion Zhuang nationality in Nanning had low rate of negative Rh ( D) and distribution of ABO was characteristic of minority in this area, i.e.rate of O gene was high and rate of A gene was low .