CAJ | 학술논문

背景：目前关于经皮椎体成形中注射聚甲基丙烯酸甲酯骨水泥对患者心血管系统及呼吸系统不良反应影响的系统性研究非常有限。 　　目的：探讨经皮椎体成形中使用聚甲基丙烯酸甲酯骨水泥对患者心血管系统的影响。 　　方法：回顾性分析2011年7月至2013年9月经皮椎体成形治疗患者的临床资料，共104例167个椎体，根据麻醉记录对局部麻醉前、聚甲基丙烯酸甲酯注射前、聚甲基丙烯酸甲酯注射后0，3，5，10 min 6个时间点的平均动脉压、心率及血氧饱和度进行比较分析。 　　结果与结论：与聚甲基丙烯酸甲酯注射前相比，聚甲基丙烯酸甲酯注射后0，3，5 min均出现平均动脉压下降，以3 min时最为明显(P<0.05，P<0.01)，10 min时恢复到注射前水平；同时心率也表现为聚甲基丙烯酸甲酯注射后0，3，5 min时间点明显加快，同样以3 min时最为明显(P<0.05，P<0.01)，10 min时心率基本恢复到注射前水平。聚甲基丙烯酸甲酯注射前后所有时间点的血氧饱和度均在95%以上，与聚甲基丙烯酸甲酯注射前相比，注射后各时间点的血氧饱和度百分数均无明显变化。表明经皮椎体成形中注入聚甲基丙烯酸甲酯会对患者心血管系统产生一过性的影响。
배경：목전관우경피추체성형중주사취갑기병희산갑지골수니대환자심혈관계통급호흡계통불량반응영향적계통성연구비상유한。 　　목적：탐토경피추체성형중사용취갑기병희산갑지골수니대환자심혈관계통적영향。 　　방법：회고성분석2011년7월지2013년9월경피추체성형치료환자적림상자료，공104례167개추체，근거마취기록대국부마취전、취갑기병희산갑지주사전、취갑기병희산갑지주사후0，3，5，10 min 6개시간점적평균동맥압、심솔급혈양포화도진행비교분석。 　　결과여결론：여취갑기병희산갑지주사전상비，취갑기병희산갑지주사후0，3，5 min균출현평균동맥압하강，이3 min시최위명현(P<0.05，P<0.01)，10 min시회복도주사전수평；동시심솔야표현위취갑기병희산갑지주사후0，3，5 min시간점명현가쾌，동양이3 min시최위명현(P<0.05，P<0.01)，10 min시심솔기본회복도주사전수평。취갑기병희산갑지주사전후소유시간점적혈양포화도균재95%이상，여취갑기병희산갑지주사전상비，주사후각시간점적혈양포화도백분수균무명현변화。표명경피추체성형중주입취갑기병희산갑지회대환자심혈관계통산생일과성적영향。
BACKGROUND:The study on polymethylmethacrylate effects on the cardiovascular system during percutaneous vertebroplasty is limited. OBJECTIVE:To estimate the effects of polymethylmethacrylate on the cardiovascular system during percutaneous vertebroplasty. METHODS:From July 2011 to September 2013, a total of 104 patients (167 vertebral bodies) with osteoporotic vertebral compression fractures and without serious cardiovascular related basic diseases were enrol ed in this retrospective study. Mean arterial pressure, heart rate and oxygen saturation were recorded at the fol owing time points:before local anesthesia, before polymethylmethacrylate injection, 0, 3, 5 and 10 minutes after polymethylmethacrylate injection. RESULTS AND CONCLUSION:The mean arterial pressure was decreased after polymethylmethacrylate injection at 0, 5 minutes (P<0.05) and 3 minutes (P<0.01), and returned to the pre-injection level at 10 minutes. At the same time, the heart rate was increased after polymethylmethacrylate injection at 0, 5 minutes (P<0.05) and 3 minutes (P<0.01), and returned to the pre-injection level at 10 minutes. Oxygen saturation was over 95%, which was unchanged before and after polymethylmethacrylate injection. The results indicated that polymethylmethacrylate injection has a transient effect on cardiovascular system during percutaneous vertebroplasty.