世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2013年
12期
1425-1427
,共3页
肺癌%顺铂%胸腔积液%艾迪注射液
肺癌%順鉑%胸腔積液%艾迪註射液
폐암%순박%흉강적액%애적주사액
Lung Cancer%Cisplatin%Addie Injection%Hydrothorax
目的：探讨顺铂化疗联合中药制剂艾迪注射液治疗肺癌胸水的疗效。方法：将112例肺癌胸腔积水患者随机分为对照组和治疗组，每组均为56例。对照组每周胸腔内注入顺铂25 mg/m2，治疗组在对照组基础上每周胸腔内注入中药制剂艾迪注射液70 mL，治疗4周后，观察和比较两组的临床疗效，T细胞亚群水平变化，不良反应和KPS质量评分。结果：治疗组总有效率达到67.86％，显著高于对照组46.42％（P＜0.05）；治疗组治疗后CD3＋、CD4＋和CD4＋/CD8＋水平与治疗前差异无统计学意义（P＞0.05），且显著高于对照组水平（P＜0.05）；治疗组治疗后KPS平均评分为（73.90±6.46）分，显著高于对照组（67.25±6.52）分和治疗前水（ P＜0.05）；总不良反应率为33.93％，显著低于对照组66.07％（ P＜0.05）。结论：中药制剂艾迪注射液联合顺铂治疗肺癌胸腔积水，能显著改善患者免疫功能，提高患者治疗后生活质量，且不良反应轻，综合疗效优于单独采用顺铂治疗。
目的：探討順鉑化療聯閤中藥製劑艾迪註射液治療肺癌胸水的療效。方法：將112例肺癌胸腔積水患者隨機分為對照組和治療組，每組均為56例。對照組每週胸腔內註入順鉑25 mg/m2，治療組在對照組基礎上每週胸腔內註入中藥製劑艾迪註射液70 mL，治療4週後，觀察和比較兩組的臨床療效，T細胞亞群水平變化，不良反應和KPS質量評分。結果：治療組總有效率達到67.86％，顯著高于對照組46.42％（P＜0.05）；治療組治療後CD3＋、CD4＋和CD4＋/CD8＋水平與治療前差異無統計學意義（P＞0.05），且顯著高于對照組水平（P＜0.05）；治療組治療後KPS平均評分為（73.90±6.46）分，顯著高于對照組（67.25±6.52）分和治療前水（ P＜0.05）；總不良反應率為33.93％，顯著低于對照組66.07％（ P＜0.05）。結論：中藥製劑艾迪註射液聯閤順鉑治療肺癌胸腔積水，能顯著改善患者免疫功能，提高患者治療後生活質量，且不良反應輕，綜閤療效優于單獨採用順鉑治療。
목적：탐토순박화료연합중약제제애적주사액치료폐암흉수적료효。방법：장112례폐암흉강적수환자수궤분위대조조화치료조，매조균위56례。대조조매주흉강내주입순박25 mg/m2，치료조재대조조기출상매주흉강내주입중약제제애적주사액70 mL，치료4주후，관찰화비교량조적림상료효，T세포아군수평변화，불량반응화KPS질량평분。결과：치료조총유효솔체도67.86％，현저고우대조조46.42％（P＜0.05）；치료조치료후CD3＋、CD4＋화CD4＋/CD8＋수평여치료전차이무통계학의의（P＞0.05），차현저고우대조조수평（P＜0.05）；치료조치료후KPS평균평분위（73.90±6.46）분，현저고우대조조（67.25±6.52）분화치료전수（ P＜0.05）；총불량반응솔위33.93％，현저저우대조조66.07％（ P＜0.05）。결론：중약제제애적주사액연합순박치료폐암흉강적수，능현저개선환자면역공능，제고환자치료후생활질량，차불량반응경，종합료효우우단독채용순박치료。
Objective:To study the curative effect of Addie injection of traditional Chinese medicine combined with cisplatin on patients with lung cancer and hydrothorax .Methods:A total number of 112 patients of lung cancer with hydrothorax were randomly divided into the control group and the observation group ,with 56 cases in each group.The control group gave patients intra-pleural injection of 25 mg/m2 of cisplatin weekly while the observation group weekly applied intra-pleural injection of 70 mL of traditional Chinese medicine Ad-die except from the same medicine of the control group .The clinical effects ,the changes of T cell subsets ,the toxicity and KPS quality score between two groups after the treatment were compared after 4 weeks of treatment .Results:The total effective rate in the observation group reached to 67.86%,which was significantly higher than that of the control group 46.42% (P <0.05); After treatment,the CD3 +,CD4 +and CD4 +/CD8 +levels in the observation had no significant difference compared with those before treatment ( P >0.05),however significantly higher than those of the control group after treatment (P<0.05); KPS average score of the observation group after treatment was (73.90 ±6.46),which was significantly higher than that of the control group (67.25 ±6.52) and before treatment (P<0.05);the total side effect rate of the observation group was 33.93%,significantly lower than that of the control group 66.07%(P<0.05).Conclusion:Addie injection of traditional Chinese medicine combined with cisplatin could significantly improve the immune function of patients ,improve the quality of life of patients after treatment with slight side effects ,which shows that the com-prehensive curative effect is better than the single application of cisplatin treatment .
