CAJ | 학술논문

目的：调查儿童各年龄段鹅口疮发病情况和各类抗真菌药物的敏感性。方法：收集2012年到哈尔滨市儿童医院口腔科就诊的655例鹅口疮患儿，划分为新生儿组、婴儿组和幼儿组，分析各年龄段的疾病分布。其中241例用棉拭子法采集患者口腔粘膜病变部位的白念菌进行细菌培养，选取制霉菌素、酮康唑、伊曲康唑和氟康唑，进行体外抗真菌药敏敏感度试验，各年龄段进行对比。结果：新生儿组和婴儿组患病率相似，幼儿组患病率最低。婴儿组大多数患儿单纯患鹅口疮，而幼儿组患儿多合并其他疾病。药物有效率（敏感和中介例数所占的比例）最高的药物分别是：新生儿组：氟康唑，婴儿组：酮康唑，幼儿组：酮康唑和氟康唑。结论：各年龄段鹅口疮发病情况有差异，治疗敏感药物不同，临床用药应参考药敏结果进行选择。
목적：조사인동각년령단아구창발병정황화각류항진균약물적민감성。방법：수집2012년도합이빈시인동의원구강과취진적655례아구창환인，화분위신생인조、영인조화유인조，분석각년령단적질병분포。기중241례용면식자법채집환자구강점막병변부위적백념균진행세균배양，선취제매균소、동강서、이곡강서화불강서，진행체외항진균약민민감도시험，각년령단진행대비。결과：신생인조화영인조환병솔상사，유인조환병솔최저。영인조대다수환인단순환아구창，이유인조환인다합병기타질병。약물유효솔（민감화중개례수소점적비례）최고적약물분별시：신생인조：불강서，영인조：동강서，유인조：동강서화불강서。결론：각년령단아구창발병정황유차이，치료민감약물불동，림상용약응삼고약민결과진행선택。
Objective:To discuss incidence and all kinds of antifungal drugs sensitivity on thrush of different ages children . Methods:Selected 655 children with thrush who visited the Department of Stomatology in Harbin Children's Hospital in 2012.Di-vided them into neonatal group, Infants group and young children group.241 cases of different groups accepted the test of antifungal drug sensitivity in vitro with nystatin, ketoconazole, itraconazole and fluconazolein respectively.Results:Prevalence rate in neonatal group is similar to which in infants group.It is the lowest in young children group.Most children in infant group uncomplicated thrush, while the children in young children group were the opposite.Drug with the highest efficiency( the proportion of sensitivity and intermediate cases) is:fluconazole in neonatal group, ketoconazole in infant group, ketoconazole and fluconazole in young chil-dren group.Conclusion:The incidence and drug sensitive of thrush is different among three groups.Clinical medical selection should refer to the drug sensitivity results.