临床儿科杂志
臨床兒科雜誌
림상인과잡지
2013年
12期
1151-1153
,共3页
先天性心脏病%基质细胞衍生因子1%肺动脉高压
先天性心髒病%基質細胞衍生因子1%肺動脈高壓
선천성심장병%기질세포연생인자1%폐동맥고압
congenital heart disease%stromal-cell-derived factor 1%pulmonary arterial hypertension
目的：探讨先天性心脏病（CHD）伴肺动脉高压患儿血清基质细胞衍生因子1（SDF-1）水平的变化。方法66例CHD患儿，采用心脏彩色多普勒超声测算三尖瓣返流速度，并估算肺动脉收缩压；根据肺动脉压，分为无肺高压组16例，轻度肺高压组18例，中度肺高压组17例，重度肺高压组15例；另20例健康儿童作为对照组。以ELISA法检测并比较各组患儿血清SDF-1水平。结果各组CHD患儿与对照组的血清SDF-1水平差异有统计学意义（F=27.793，P<0.001）。各组CHD患儿的SDF-1水平均低于对照组；CHD患儿中，重度肺高压组的血清SDF-1水平最低，无肺高压组的血清SDF-1水平最高，各组间的差异均有统计学意义（P均<0.05）。CHD患儿的肺动脉收缩压与血清SDF-1水平呈负相关（r=-0.737，P<0.001）。结论血清SDF-1水平在CHD患儿中下降，并且与肺动脉高压的严重程度呈负相关。
目的：探討先天性心髒病（CHD）伴肺動脈高壓患兒血清基質細胞衍生因子1（SDF-1）水平的變化。方法66例CHD患兒，採用心髒綵色多普勒超聲測算三尖瓣返流速度，併估算肺動脈收縮壓；根據肺動脈壓，分為無肺高壓組16例，輕度肺高壓組18例，中度肺高壓組17例，重度肺高壓組15例；另20例健康兒童作為對照組。以ELISA法檢測併比較各組患兒血清SDF-1水平。結果各組CHD患兒與對照組的血清SDF-1水平差異有統計學意義（F=27.793，P<0.001）。各組CHD患兒的SDF-1水平均低于對照組；CHD患兒中，重度肺高壓組的血清SDF-1水平最低，無肺高壓組的血清SDF-1水平最高，各組間的差異均有統計學意義（P均<0.05）。CHD患兒的肺動脈收縮壓與血清SDF-1水平呈負相關（r=-0.737，P<0.001）。結論血清SDF-1水平在CHD患兒中下降，併且與肺動脈高壓的嚴重程度呈負相關。
목적：탐토선천성심장병（CHD）반폐동맥고압환인혈청기질세포연생인자1（SDF-1）수평적변화。방법66례CHD환인，채용심장채색다보륵초성측산삼첨판반류속도，병고산폐동맥수축압；근거폐동맥압，분위무폐고압조16례，경도폐고압조18례，중도폐고압조17례，중도폐고압조15례；령20례건강인동작위대조조。이ELISA법검측병비교각조환인혈청SDF-1수평。결과각조CHD환인여대조조적혈청SDF-1수평차이유통계학의의（F=27.793，P<0.001）。각조CHD환인적SDF-1수평균저우대조조；CHD환인중，중도폐고압조적혈청SDF-1수평최저，무폐고압조적혈청SDF-1수평최고，각조간적차이균유통계학의의（P균<0.05）。CHD환인적폐동맥수축압여혈청SDF-1수평정부상관（r=-0.737，P<0.001）。결론혈청SDF-1수평재CHD환인중하강，병차여폐동맥고압적엄중정도정부상관。
Objective To assess the serum level of stromal-cell-derived factor 1 (SDF-1) in patients with congenital heart disease (CHD) and pulmonary arterial hypertension. Methods The heart color Doppler ultrasound was conducted to measure the tricuspid regurgitation velocity, in order to estimate pulmonary artery systolic pressure. According to the existing standards, a total of 86 patients were divided into CHD without pulmonary hypertension group (n=16), mild pulmonary hypertension group (n=18), moderate pulmonary hypertension group (n=17), severe pulmonary hypertension group (n=15). Another 20 healthy chil-dren were recruited as control group (n=20), The serum level of SDF-1 was detected by the ELISA method. Results The serum SDF-1 levels were signiifcantly lower in CHD groups than in control group (F=27.793, P<0.001). In CHD groups, CHD with se-vere pulmonary hypertension group had the lowest SDF-1 level, and CHD without pulmonary hypertension group had the highest SDF-1 level. There were signiifcant differences between CHD groups (P<0.05). The pulmonary artery systolic pressure was cor-related with serum SDF-1 levels (r=-0.737, P<0.001). Conclusions The serum level of SDF-1 is decreased in patients with CHD, and is negatively correlated with the severity of pulmonary arterial hypertension.
