临床儿科杂志
臨床兒科雜誌
림상인과잡지
2013年
12期
1129-1133
,共5页
彭文婧%焦莉平%陈植%沈颖
彭文婧%焦莉平%陳植%瀋穎
팽문청%초리평%진식%침영
慢性肾脏病%左心室肥大%危险因素%儿童
慢性腎髒病%左心室肥大%危險因素%兒童
만성신장병%좌심실비대%위험인소%인동
chronic kidney disease%left ventricular hypertrophy%risk factors%child
目的：探讨慢性肾脏病（CKD）患儿左心室肥大（LVH）发生率及其相关危险因素。方法回顾性分析住院CKD患儿的临床资料，包括生化指标、血压和超声心动图。并采用Logistic回归分析LVH发生危险因素。结果125例CKD患儿中，4期40例（32.00%），5期85例（68.00%）。CKD 4期患儿的估计肾小球滤过率（eGFR）、血红蛋白（Hb）均高于5期患儿，而全段甲状旁腺激素（iPTH）、血磷和左心室质量指数（LVMI）均低于5期患儿，差异有统计学意义（P均<0.01）；LVH患儿42例（33.60%），非LVH患儿83例（66.40%），LVH患儿的eGFR和Hb均低于非LVH患儿，而iPTH、血磷、收缩压和舒张压均高于非LVH患儿，差异有统计学意义（P均<0.05）。Logistic回归分析提示，高血压、高血磷、中重度贫血是LVH发生的危险因素。结论控制血压、纠正贫血和磷代谢紊乱可能是防治LVH的关键。[临床儿科杂志,2013,31(12)：1129-1133]
目的：探討慢性腎髒病（CKD）患兒左心室肥大（LVH）髮生率及其相關危險因素。方法迴顧性分析住院CKD患兒的臨床資料，包括生化指標、血壓和超聲心動圖。併採用Logistic迴歸分析LVH髮生危險因素。結果125例CKD患兒中，4期40例（32.00%），5期85例（68.00%）。CKD 4期患兒的估計腎小毬濾過率（eGFR）、血紅蛋白（Hb）均高于5期患兒，而全段甲狀徬腺激素（iPTH）、血燐和左心室質量指數（LVMI）均低于5期患兒，差異有統計學意義（P均<0.01）；LVH患兒42例（33.60%），非LVH患兒83例（66.40%），LVH患兒的eGFR和Hb均低于非LVH患兒，而iPTH、血燐、收縮壓和舒張壓均高于非LVH患兒，差異有統計學意義（P均<0.05）。Logistic迴歸分析提示，高血壓、高血燐、中重度貧血是LVH髮生的危險因素。結論控製血壓、糾正貧血和燐代謝紊亂可能是防治LVH的關鍵。[臨床兒科雜誌,2013,31(12)：1129-1133]
목적：탐토만성신장병（CKD）환인좌심실비대（LVH）발생솔급기상관위험인소。방법회고성분석주원CKD환인적림상자료，포괄생화지표、혈압화초성심동도。병채용Logistic회귀분석LVH발생위험인소。결과125례CKD환인중，4기40례（32.00%），5기85례（68.00%）。CKD 4기환인적고계신소구려과솔（eGFR）、혈홍단백（Hb）균고우5기환인，이전단갑상방선격소（iPTH）、혈린화좌심실질량지수（LVMI）균저우5기환인，차이유통계학의의（P균<0.01）；LVH환인42례（33.60%），비LVH환인83례（66.40%），LVH환인적eGFR화Hb균저우비LVH환인，이iPTH、혈린、수축압화서장압균고우비LVH환인，차이유통계학의의（P균<0.05）。Logistic회귀분석제시，고혈압、고혈린、중중도빈혈시LVH발생적위험인소。결론공제혈압、규정빈혈화린대사문란가능시방치LVH적관건。[림상인과잡지,2013,31(12)：1129-1133]
Objectives To investigate the prevalence of left ventricular hypertrophy (LVH) and risk factors in children with chronic kidney disease (CKD). Methods The biochemical indices, blood pressure and left ventricular mass index (LVMI) in pa-tients with CKD were retrospectively analyzed. The risk factors of LVH were analyzed using Logistic regression. Results In 125 CKD patients, 32.00%were at 4th stage and 68.00%were at 5th stage. The estimate glomerular ifltration rate (eGFR) and hemo-globin (Hb) level were signiifcantly higher in CKD patients at 4th stage than in those at 5th stage. The intact parathyroid hormone (iPTH), serum phosphorus and LVMI were signiifcantly lower in CKD patients at 4th stage than in those at 5th stage (P<0.01). LVH was detected in 33.60%CKD patients. The eGFR and Hb level were signiifcantly lower in CKD patients with LVH than in those without LVH. The iPTH, serum phosphorus, systolic blood pressure and diastolic blood pressure were signiifcantly higher in CKD patients with LVH than in those without LVH (P<0.05). Logistic regression analysis indicated that only hypertension, hyperphosphatemia, moderate and severe anemia were the risk factors of LVH. Conclusion Control of hypertension, hyperphos-phatemia and anemia is the key to prevent LVH in CKD patients.
