CAJ | 학술논문

目的：评价和监测促性腺激素释放激素类似物（GnRHa）治疗的有效性。方法30例经黄体生成素释放激素（LHRH）激发试验明确诊断的真性性早熟（CPP）女童，予GnRHa治疗6~24个月；治疗3个月及其后每6个月均行LHRH激发试验；比较LH峰值与临床发育受抑情况（包括发育分期、骨龄和生长速率）；评估LH峰值对GnRHa治疗的监测作用。结果共完成90次LHRH激发试验，仅7次有临床发育。治疗6个月后，30例女童的基础LH值为（0.48±0.20）IU/L，低于治疗前的（0.75±0.35）IU/L，差异有统计学意义（P=0.000）；基础LH值与LH峰值的相关系数为0.62（P=0.022）。LHRH激发试验LH峰值<2 IU/L时，临床发育受抑情况最好（灵敏度85.7%，特异度100%）。结论基础LH值可用于评估CPP女童GnRHa治疗疗效。LHRH激发试验LH峰值<2 IU/L可作为GnRHa治疗有效的指标。
목적：평개화감측촉성선격소석방격소유사물（GnRHa）치료적유효성。방법30례경황체생성소석방격소（LHRH）격발시험명학진단적진성성조숙（CPP）녀동，여GnRHa치료6~24개월；치료3개월급기후매6개월균행LHRH격발시험；비교LH봉치여림상발육수억정황（포괄발육분기、골령화생장속솔）；평고LH봉치대GnRHa치료적감측작용。결과공완성90차LHRH격발시험，부7차유림상발육。치료6개월후，30례녀동적기출LH치위（0.48±0.20）IU/L，저우치료전적（0.75±0.35）IU/L，차이유통계학의의（P=0.000）；기출LH치여LH봉치적상관계수위0.62（P=0.022）。LHRH격발시험LH봉치<2 IU/L시，림상발육수억정황최호（령민도85.7%，특이도100%）。결론기출LH치가용우평고CPP녀동GnRHa치료료효。LHRH격발시험LH봉치<2 IU/L가작위GnRHa치료유효적지표。
Objective To evaluate and monitor the efifcacy of GnRH analogs (GnRHa) therapy. Methods Thirty girls with central precocious puberty diagnosied by LHRH stimulation test were treated with GnRHa for 6-24 months. The LHRH stimula-tion test were performed again at 3 months after initiation of therapy and then every 6 months during treatment. The relationship of peark LH and clinical suppressing pubertal (including Turner stage, bone age, grwoth speed) were compared. The monitor effect of peak LH to efifcacy of GnRHa were eveluated. Results Ninety LHRH stimulation tests were performed, only 7 cases were found to have clinical pubertal development. After 6 months treatment, the base LH level of thirty girls (0.48±0.20) IU/L was signiifcantly lower than that before the treatment (0.75±0.35 IU/L) (P=0.000). The correlation coefifcient between base LH and peak LH was 0.62. The best correlation between clinical suppressing pubertal and LHRH stimulation test was achieved when peak LH was less than 2 IU/L (85.7%sensitivity, 100%speciifcity). Conclusions Base LH value can be used in preliminary as-sessment of the efifcacy of GnRHa therapy for girls with central precocious puberty. The peak LH less than 2 IU/L can be as the indicator of treatment efifcacy.