CAJ | 학술논문

目的：观察GP和NP化疗方案治疗晚期非小细胞肺癌的临床疗效和安全性。方法：以我院2010年1月-2011年12月间应用NP方案治疗的51例晚期非小细胞肺癌患者为NP组，以我院同期应用GP化疗方案治疗的51例患者为GP组，比较两组患者治疗有效率、疾病控制率、1年生存率及严重药物副反应发生率情况。结果：两组患者治疗有效率和疾病控制率相当，（（P＞0．05）。GP组1年生存率显著高于NP组，严重药物副反应发生率显著低于NP组。结论：应用GP化疗方案治疗晚期非小细胞肺癌可取得与NP方案相当的疗效，但患者是生存率较高，严重毒副反应较少，值得临床进一步推广应用。
목적：관찰GP화NP화료방안치료만기비소세포폐암적림상료효화안전성。방법：이아원2010년1월-2011년12월간응용NP방안치료적51례만기비소세포폐암환자위NP조，이아원동기응용GP화료방안치료적51례환자위GP조，비교량조환자치료유효솔、질병공제솔、1년생존솔급엄중약물부반응발생솔정황。결과：량조환자치료유효솔화질병공제솔상당，（（P＞0．05）。GP조1년생존솔현저고우NP조，엄중약물부반응발생솔현저저우NP조。결론：응용GP화료방안치료만기비소세포폐암가취득여NP방안상당적료효，단환자시생존솔교고，엄중독부반응교소，치득림상진일보추엄응용。
objective:to observe the GP and NP chemotherapy for treatment of advanced non-smal celllung cancer clinical ef icacy and safety.Methods:from January 2010 to Decem-ber2011betweentheapplicationof51casesofNPregimenforadvancednon-smal celllungcancerpatientsforNPgroup,withthesameperiodinourapplicationofGPchemotherapyregimen for 5 1 patients for GP group,compared two groups of patients ef ectively,disease control,1 year survival rate and incidence of serious drug side ef ects.Results:two groups of patients to be ef i-cient and disease control,((P >0.05).The GP group 1 year survival rate was significantly higher than that of NP group,incidence of serious drug adverse reactions was significantly lower than NP group.Conclusion:the use of GP chemotherapy regimens for advanced non-smal -celllung cancer (NSCLC)can be obtained and the curative ef ect of NP plan is,but patients be-cause of its higher survival rate,less serious adverse reaction,is worth further clinical application.