CAJ | 학술논문

目的观察唑来膦酸联合VADM方案(长春新碱、吡柔比星、地塞米松、美法仑)治疗老年患者多发性骨髓瘤骨痛的疗效.方法选取符合诊断标准的多发性骨髓瘤老年患者44例,随机分成治疗组(24例)和对照组(20例).对照组只予VADM方案化疗,治疗组应用唑来膦酸联合VADM方案,比较两组疗效、总有效率情况.结果治疗组总有效率91.67％,对照组总有效率70％,两组比较差异具有统计学意义(P＜0.05).结论唑来膦酸联合VADM方案治疗,可以显著缓解多发性骨髓瘤骨痛.
목적 관찰서래련산연합VADM방안(장춘신감、필유비성、지새미송、미법륜)치료노년환자다발성골수류골통적료효.방법 선취부합진단표준적다발성골수류노년환자44례,수궤분성치료조(24례)화대조조(20례).대조조지여VADM방안화료,치료조응용서래련산연합VADM방안,비교량조료효、총유효솔정황.결과 치료조총유효솔91.67％,대조조총유효솔70％,량조비교차이구유통계학의의(P＜0.05).결론 서래련산연합VADM방안치료,가이현저완해다발성골수류골통.
Objective To observe the clinical efficacy of Zoledronic acid combined with VADM chemotherapy (Vincristine,Pirarubicin,Dexamethasone,Melphalan) in the treatment of multiple myeloma bone pain in elderly patients.Methods 44 elderly patients with multiple myeloma in accordance with diagnostic criteria were randomly divided into two groups.The therapy group (24 cases) received Zoledronic acid combined with VADM chemotherapy,while the control group (20 cases) received VADM chemotherapy only.The treatment effect and total effective rate were observed and compared.Result The total effective rate of the therapy group was 91.67％,while that of the control group was 70.00％,with significant difference between two groups (P ＜ 0.05).Conclusion Zoledronic acid combined with VADM chemotherapy can effectively relieve bone pain in elderly patients with multiple myeloma.