CAJ | 학술논문

比较豚鼠、SD 大鼠、Wistar 大鼠对牛血清白蛋白（bovine serum albumin BSA）诱导的被动皮肤过敏（passive cutaneous anaphylaxis PCA）反应的差异性，力求寻找更为敏感的模型动物。选用豚鼠、SD 大鼠、Wistar 大鼠，以 BSA 为致敏原，PCA 反应时出现蓝斑的直径及阳性反应率作为判别标准。结果表明，豚鼠、大鼠对 BSA 的敏感性存在较大差异，豚鼠对 BSA 的敏感性较强，豚鼠是一种用于 PCA 试验较好的模型动物。
비교돈서、SD 대서、Wistar 대서대우혈청백단백（bovine serum albumin BSA）유도적피동피부과민（passive cutaneous anaphylaxis PCA）반응적차이성，력구심조경위민감적모형동물。선용돈서、SD 대서、Wistar 대서，이 BSA 위치민원，PCA 반응시출현람반적직경급양성반응솔작위판별표준。결과표명，돈서、대서대 BSA 적민감성존재교대차이，돈서대 BSA 적민감성교강，돈서시일충용우 PCA 시험교호적모형동물。
Comparison of the different sensitivity of passive cutaneous anaphylaxis(PCA)on guinea pigs, Sprague Dawley(SD)rats and Wistar rats caused by BSA was conducted in order to find more sensitive an-imal model in PCA test.PCA was performed by using guinea pigs,SD rats and Wistar rats,and BSA was taken as allergen.The diameter of dermal Evan′s blue spot and the positive reaction rate were measured to discriminate severity of PCA on three animals.Guinea pigs and rats to BSA have large differences The guinea pigs were the most sensitive animals to BSA.The guinea pig is the best animal model which can be used in PCA test.