CAJ | 학술논문

目的：观察培美曲塞联合顺铂与多西他赛联合顺铂治疗晚期肺腺癌的疗效及不良反应。方法：晚期肺腺癌52例患者随机分为2组，治疗组26例采用培美曲塞联合顺铂治疗，对照组采用多西他赛联合顺铂治疗，治疗2个周期后评价疗效，治疗期间观察不良反应。结果：治疗组总有效率25％，疾病控制率50％，对照组总有效率23％，疾病控制率为48％，2组比较差异无统计学意义。但是治疗组骨髓抑制及胃肠道反应等显著低于对照组，2组比较有统计学意义。结论：培美曲塞或多西他赛联合顺铂治疗晚期肺腺癌疗效确切，疗效相似，但培美曲塞联合顺铂不良反应更轻，已成为晚期肺腺癌的一线治疗的重要选择。
목적：관찰배미곡새연합순박여다서타새연합순박치료만기폐선암적료효급불량반응。방법：만기폐선암52례환자수궤분위2조，치료조26례채용배미곡새연합순박치료，대조조채용다서타새연합순박치료，치료2개주기후평개료효，치료기간관찰불량반응。결과：치료조총유효솔25％，질병공제솔50％，대조조총유효솔23％，질병공제솔위48％，2조비교차이무통계학의의。단시치료조골수억제급위장도반응등현저저우대조조，2조비교유통계학의의。결론：배미곡새혹다서타새연합순박치료만기폐선암료효학절，료효상사，단배미곡새연합순박불량반응경경，이성위만기폐선암적일선치료적중요선택。
Objective :To observe the effect and adverse reaction of Pemetrexed or Docetaxel plus Cisplatin in treatment of advanced lung adenocarcinoma .Methods :52 cases of advanced lung adenocarcinoma patients were randomly divided into two groups ,26 cases in the treatment group were treated with Pemetrexed combined with Cisplatin treatment , control group with docetaxel plus Cisplatin treatment ,efficacy of treatment was evaluated after 2 cycles ,the adverse reactions were observed during treatment .Results:The total effective rate was 25% in treatment group and 23% in comparison group ,disease control rate was 50% in treatment group and 48% in comparison group ,no significant sta-tistical differences between the two groups .But the myelosuppression and gastrointestinal tract reaction in treatment group were significantly lower than those in the control group ,the two groups was statistically significant .Conclusion:The efficacy of Pemetrexed or Docetaxel plus Cisplatin was definite and similar ,but the adverse reactions of peme-trexed combined with cisplatin is lighter ,so it has become an important option for first-line treatment of advanced lung adenocarcinoma .