CAJ | 학술논문

急性脊髓损伤可导致严重的运动、感觉功能障碍，由自由基引起的氧化应激在继发性脊髓损伤的病理生理过程中占有重要地位。通过有效的抗氧化干预抑制损伤后生物大分子的过氧化反应，将成为药物治疗脊髓损伤的一条策略。本文主要介绍氧化应激的产生原因、作用过程和参与急性脊髓损伤的病理生理机制，并综述抗氧化药物实验研究的最新进展，旨在为寻找安全有效的药物提供参考依据。
급성척수손상가도치엄중적운동、감각공능장애，유자유기인기적양화응격재계발성척수손상적병리생리과정중점유중요지위。통과유효적항양화간예억제손상후생물대분자적과양화반응，장성위약물치료척수손상적일조책략。본문주요개소양화응격적산생원인、작용과정화삼여급성척수손상적병리생리궤제，병종술항양화약물실험연구적최신진전，지재위심조안전유효적약물제공삼고의거。
Acute spinal cord injury can lead to severe motor and sensory dysfunction. Oxidative stress caused by free radical plays an important role in the pathophysiology of secondary injury. Inhibition of biological macromolecules peroxidation damage through antioxidant intervention may be an effective strategy for drug therapy of spinal cord injury. This paper mainly introduces the cause,process and participation of oxidative stress in the pathophysiological mechanism of acute spinal cord injury,and also reviews the recent advances in antioxidant drug research,aiming to facilitate the discovery of safe and effective antioxidant drugs for potential treatment of acute spinal cord injury.